Tricyclic, anti-depressant drugs were developed from the observation that some tricyclic, anti-psychotic drugs elevated a patient’s mood. Identify the structural features of a tricyclic drug that were found to affect its action as a pure anti-depressant or a mixed anti-psychotic/anti-depressant agent and comment on the structural modifications that can be made to such an anti-depressant drug whilst retaining the essential pharmacophore.

Tricyclic, anti-depressant drugs were developed from the observation that some tricyclic, anti-psychotic drugs elevated a patient’s mood. Identify the structural features of a tricyclic drug that were found to affect its action as a pure anti-depressant or a mixed anti-psychotic/anti-depressant agent and comment on the structural modifications that can be made to such an anti-depressant drug whilst retaining the essential pharmacophore.

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter16: Gastrointestinal Drugs

Section: Chapter Questions

Problem 16CRQ

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