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Researchers who study those rods cells have performed a series of experiments to better understand this phototransduction pathway and the role of this PDE protein in patients that suffer from night blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic- GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the PDE6i inhibitor. The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity increases, but only in the absence of the PDE6i inhibitor (see figure below). Without PDE6i cGMP concentration (A.U) 25 20- 15- 10- 0- 0 0.1 A.U (Arbitraty Unit) 0.2 0.3 Light intensity (A.U) 25 - 20 0.4 15 5 0 GMP concentration (A.U) cGMP concentration (A.U) 25 20- 15- 10- 5 0 0 0.1 With PDE6i 0.2 0.3 Light intensity (A.U) 0.4 C. The PDE protein is an oxidase that reduces GMP into a cGMP D. The PDE protein is a phosphodiesterase that converts CGMP into a GMP E. The PDE protein is an electron carrier that transfers an electron to the GMP 25 -15 A. The PDE protein is a protein kinase that phosphorylates and activates the rhodopsin B. The PDE protein is a phosphatase that removes a phosphate group from GMP and produces cGMP 20 5 9. Given these experimental results and the inhibitory role of PDE6i, what is the likely function of the PDE protein when it is being activated by the transducin (i.e. in the presence of light)? 0 GMP concentration (A.U)

Researchers who study those rods cells have performed a series of experiments to better understand this phototransduction pathway and the role of this PDE protein in patients that suffer from night blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic- GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the PDE6i inhibitor. The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity increases, but only in the absence of the PDE6i inhibitor (see figure below). Without PDE6i cGMP concentration (A.U) 25 20- 15- 10- 0- 0 0.1 A.U (Arbitraty Unit) 0.2 0.3 Light intensity (A.U) 25 - 20 0.4 15 5 0 GMP concentration (A.U) cGMP concentration (A.U) 25 20- 15- 10- 5 0 0 0.1 With PDE6i 0.2 0.3 Light intensity (A.U) 0.4 C. The PDE protein is an oxidase that reduces GMP into a cGMP D. The PDE protein is a phosphodiesterase that converts CGMP into a GMP E. The PDE protein is an electron carrier that transfers an electron to the GMP 25 -15 A. The PDE protein is a protein kinase that phosphorylates and activates the rhodopsin B. The PDE protein is a phosphatase that removes a phosphate group from GMP and produces cGMP 20 5 9. Given these experimental results and the inhibitory role of PDE6i, what is the likely function of the PDE protein when it is being activated by the transducin (i.e. in the presence of light)? 0 GMP concentration (A.U)

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Researchers who study those rods cells have performed a series of experiments to better understand this phototransduction pathway and the role of this PDE protein in patients that suffer from night blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic- GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the PDE6i inhibitor. The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity increases, but only in the absence of the PDE6i inhibitor (see figure below). Without PDE6i cGMP concentration (A.U) 25 20 15- 10- 0 0 0.1 A.U (Arbitraty Unit) 0.2 0.3 Light intensity (A.U) 25 -20 -15 -10 -5 0.4 0 GMP concentration (A.U) cGMP concentration (A.U) 25 20- 15- 10 0- 0 0.1 With PDE6i 0.2 0.3 Light intensity (A.U) -20 C. The PDE protein is an oxidase that reduces GMP into a cGMP D. The PDE protein is a phosphodiesterase that converts cGMP into a GMP E. The PDE protein is an electron carrier that transfers an electron to the GMP 25 0.4 A. The PDE protein is a protein kinase that phosphorylates and activates the rhodopsin B. The PDE protein is a phosphatase that removes a phosphate group from GMP and produces CGMP 15 -0 5 9. Given these experimental results and the inhibitory role of PDE6i, what is the likely function of the PDE protein when it is being activated by the transducin (i.e. in the presence of light)? GMP concentration (A.U)
Transcribed Image Text:Researchers who study those rods cells have performed a series of experiments to better understand this phototransduction pathway and the role of this PDE protein in patients that suffer from night blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic- GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the PDE6i inhibitor. The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity increases, but only in the absence of the PDE6i inhibitor (see figure below). Without PDE6i cGMP concentration (A.U) 25 20 15- 10- 0 0 0.1 A.U (Arbitraty Unit) 0.2 0.3 Light intensity (A.U) 25 -20 -15 -10 -5 0.4 0 GMP concentration (A.U) cGMP concentration (A.U) 25 20- 15- 10 0- 0 0.1 With PDE6i 0.2 0.3 Light intensity (A.U) -20 C. The PDE protein is an oxidase that reduces GMP into a cGMP D. The PDE protein is a phosphodiesterase that converts cGMP into a GMP E. The PDE protein is an electron carrier that transfers an electron to the GMP 25 0.4 A. The PDE protein is a protein kinase that phosphorylates and activates the rhodopsin B. The PDE protein is a phosphatase that removes a phosphate group from GMP and produces CGMP 15 -0 5 9. Given these experimental results and the inhibitory role of PDE6i, what is the likely function of the PDE protein when it is being activated by the transducin (i.e. in the presence of light)? GMP concentration (A.U)
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