You are working with a newly discovered mutagen, andyou wish to determine the base change that it introduces into DNA. Thus far, you have determined that themutagen chemically alters a single base in such a waythat its base-pairing properties are altered permanently.To determine the specificity of the alteration, you examine the amino acid changes that take place after mutagenesis. A sample of what you find is shown here:Original: Gln–His–Ile–Glu–LysMutant: Gln–His–Met–Glu–LysOriginal: Ala–Val–Asn–ArgMutant: Ala–Val–Ser–ArgOriginal: Arg–Ser–LeuMutant: Arg–Ser–Leu–Trp–Lys–Thr–PheWhat is the base-change specificity of the mutagen?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
You are working with a newly discovered mutagen, and
you wish to determine the base change that it introduces into DNA. Thus far, you have determined that the
mutagen chemically alters a single base in such a way
that its base-pairing properties are altered permanently.
To determine the specificity of the alteration, you examine the amino acid changes that take place after mutagenesis. A sample of what you find is shown here:
Original: Gln–His–Ile–Glu–Lys
Mutant: Gln–His–Met–Glu–Lys
Original: Ala–Val–Asn–Arg
Mutant: Ala–Val–Ser–Arg
Original: Arg–Ser–Leu
Mutant: Arg–Ser–Leu–Trp–Lys–Thr–Phe
What is the base-change specificity of the mutagen?
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