Within living cells, many different proteins play importantfunctional roles by binding to DNA. Some proteins bind to DNA butnot in a sequence-specific manner. For example, histones are proteinsimportant in the formation of chromosome structure. The positivelycharged histone proteins bind to the negatively charged phosphategroups in DNA. In addition, several other proteins interact with DNAbut do not require a specific nucleotide sequence to carry out theirfunction. For example, DNA polymerase, which catalyzes thesynthesis of new DNA strands, does not bind to DNA in a sequencedependent manner. By comparison, many other proteins do interact with nucleic acids in a sequence-dependent fashion. This means that a specific sequence of bases can provide a structure that isrecognized by a particular protein.Someexamples include transcription factors that affect the rate oftranscription and proteins that bind to origins of replication inbacteria.What information do you know based onthe question and based on your understanding of thetopic?
Within living cells, many different proteins play important
functional roles by binding to DNA. Some proteins bind to DNA but
not in a sequence-specific manner. For example, histones are proteins
important in the formation of chromosome structure. The positively
charged histone proteins bind to the negatively charged phosphate
groups in DNA. In addition, several other proteins interact with DNA
but do not require a specific
function. For example, DNA polymerase, which catalyzes the
synthesis of new DNA strands, does not bind to DNA in a sequencedependent manner. By comparison, many other proteins do interact with
recognized by a particular protein.Some
examples include transcription factors that affect the rate of
transcription and proteins that bind to origins of replication in
bacteria.
What information do you know based on
the question and based on your understanding of the
topic?
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