A certain membrane protein is found on the ER membrane with the N-terminus on the ER side of the membrane and the C-terminus on the cytosol side of the membrane. The protein contains three transmembrane domains. What would be the orientation of the protein across the ER membrane if the gene were mutated such that the third transmembrane domain coded for hydrophilic amino acids? (B) (C) N C =1881- N C ER LUMEN CYTOSOL (A) N Choose one: O Orientation A O Orientation B O Orientation C O Orientation D (D) N rough ER membrane

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 20QP: If an extra nucleotide is inserted in the first exon of the beta globin gene, what effect will it...
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A certain membrane protein is found on the ER membrane with the N-terminus on the ER side of the membrane and the C-terminus on
the cytosol side of the membrane. The protein contains three transmembrane domains. What would be the orientation of the protein
across the ER membrane if the gene were mutated such that the third transmembrane domain coded for hydrophilic amino acids?
(B)
(D)
N
с
N
N
=481 (-
rough
ER membrane
C
ER LUMEN
CYTOSOL
(A)
Choose one:
Orientation A
Orientation B
Orientation C
O Orientation D
(C)
N C
Transcribed Image Text:A certain membrane protein is found on the ER membrane with the N-terminus on the ER side of the membrane and the C-terminus on the cytosol side of the membrane. The protein contains three transmembrane domains. What would be the orientation of the protein across the ER membrane if the gene were mutated such that the third transmembrane domain coded for hydrophilic amino acids? (B) (D) N с N N =481 (- rough ER membrane C ER LUMEN CYTOSOL (A) Choose one: Orientation A Orientation B Orientation C O Orientation D (C) N C
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