Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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1. Certain proteins that stimulate expression of a gene bind to DNA in a sequence specific manner and also induce conformational changes in the DNA. Describe the purpose of thses two modes of interaction with the DNA.
2. Draw the structures of the amino acid side chains that correspond to the following histone modification: a) acetylation of lysine; b) phosphorylation of serine; c) phosphorylation of histidine. How do thses modifications change the character of their respective side chain?
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- Which is the expected outcome following the deacetylation of histones? a) Coiling of chromatin, preventing it from being accessed by transcriptional machinery b) Coiling of chromatin, allowing it to be accessed by transcriptional machinery c) Uncoiling of chromatin, preventing it from being accessed by transcriptional machinery d) Uncoiling of chromatin, allowing it to be accessed by transcriptional machineryarrow_forwardConsider the mechanism of the enzyme RNase: What would happen to the Km (i.e., would it increase, decrease, or stay the same) if the his12 was mutated to a lysine? Explain. What would happen to the Kcat (i.e., would it increase, decrease, or stay the same) if the his12 was mutated to a valine? Explain.arrow_forward1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Please EXCLUDE the use of CRISPR from consideration. A. Will you use germline or somatic cell gene therapy? Please NAME and DEFINE the form of gene therapy selected, then explain WHY this is the most appropriate choice.arrow_forward
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- in all cells observed to date, DNA serves as the stable, information-rivh molecule that stores genetic information. In contrast, in almost all cases, non-catalytic RNS serves as either a labile intermediate molecule involve in the production of proteins or as a labile regulatory molecule. A) based on the material, hypothesize why the molecule structures of DNA and RNA are, or are not, consistent with these two roles. B) RNA can also serve a catalytic role(ribosomes, RNA splicing, etc). What part of the RNA molecule would you predict makes it more likely than DNA to participate in enzymatic reactions? C) Explain how all these ideas may support as "RNA World Hypothesis" where RNA evolved first, followed by DNA and proteinarrow_forwardA membrane-associated protein kinase has the sequence -GMCLVS at its C-terminus, which has been shown by mutagenesis to be essential for its biological function and sub cellular location.a) What is the most likely post-translational modification that this motif would be susceptible to?b) How is this modification introduced to the protein?c) What is the likely effect of this modification on the behaviour of the protein?d) What other modification to N-terminus of the protein might achieve a similar effect on the behaviour of the protein?arrow_forward
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