Which ONE of the following molecular abnormalities is associated with the POOREST prognosis in acute myeloid leukaemia Select one: A.t(8;21) translocation (RUNX1‐RUNXT1 fusion) B.DNMT3A mutation C.TP53 deletion D.NPM1 (nucleophosmin) mutation

A genetic variant of the HBB gene results in sickle cell anemia, a disorder than primarily affects people of Sub-Saharan African descent, including many black Americans. Sickle cell anemia is named after the shape of the red blood cells in individuals with this disorder. The diseased genetic variant in the HBB gene results in a malformed hemoglobin protein, which is responsible for the shape of the red blood cell. Patients diagnosed with this disorder often exhibit a variety of symptoms, such as episodes of pain, swelling of hands and feet, delayed growth, and vision problems amongst others. The malformed hemoglobin protein is an example of the relationship between genes and traits at the:       molecular level.   population level.   cellular level.   organism level.

1. A monogenic disease is a disease caused by a mutation in a single gene. For instance, sickle-cell anemia is caused by a mutation in the HBB gene, which codes for the B- globin chain of hemoglobin. The beginning of HBB is shown here: 5'-ATGGTGCACCTGACTCCTGAGGAGAAGTCTGCCGTTACT...-3' A. Translate this HBB sequence into an amino acid sequence. B. In terms of amino acids, what is the result of the sickle cell mutation, wherein the bolded red A is changed to a T? This single mutation causes hemoglobin to aggregate, causing red blood cells to deform into a sickle-like shape rather than the normal “biconcave disk" shape. C. What would happen if the bolded blue A were mutated to at T? (This is hypothetical; it's not a mutation found in sickle-cell disease.)

Shown below are the maps of a series of rII− deletion strains (1–5). The deleted region is indicated as (......) and the intact region as ______.    1 ___________(...........)_______________    2 _________________(...........)_________    3 (.....................)_____________________    4 ________________________(................)    5 _____(..........)______________________    rII− phage strains A-E have point mutations in the rII region. E.coli K(λ) cells are coinfected with one phage that has a deletion and one phage that has a point mutation. The presence of wild-type progeny phage is assessed by the presence (+) or absence (o) of plaques.       1 2 3 4 5 A + o + + + B o + + + + C + + + o + D + + o + + E + + o + o           A) Indicate the order of the point mutations in the rII region. A) CADBE  B) DEBAC C) BADCE D) ABDEC E) CEADB B)  The test described here is a recombination test. Explain…

Please help, doesn't it usually start before the promoter or after, please just give me a brief explanation

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Notice the comment that after treatment your CD4 count should rise. Why does treatment allow CD4s to increase?   A Anti-retroviral therapy consists of transfusions of CD4 cells.   B Anti-retroviral therapy directly stimulates cell division of CD4 cells, so their numbers increase.   C Anti-retroviral therapy will prevent HIV from replicating and killing your CD4s. CD4s can grow back to some degree.

Which of the following mutations would produce a form of the Ras protein that would be more difficult to inactivate than normal Ras? Briefly explain your reasoning.(i) A mutation that allows Ras to cleave (hydrolyze) GTP more rapidly than usual(ii) A mutation that causes Ras to bind Ras-GAP more tightly than usual(iii) A mutation that causes Ras to cleave (hydrolyze) GTP more slowly than usual

Options for answers in the above picture - pick one.  A. H-NS B. IHF C. Histone H1 D. DPS E. Fis

Which of the following statements are correct about inflammation and cancer (select all that apply)?   A. Inflammatory cells are often detected in tumor samples   B. The inflammatory cytokine TNF has been shown to have direct transforming properties   C. Cancer often arises at sites of chronic inflammation   D. Use of NSAIDs has been associated with increased mortality from colorectal cancer   E. Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosis