Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Transcribed Image Text:10-
00
O
SCNSA-SCN10A
CDKN1A
HANDI
VTI1A
SYTI
•
MYOCD
9 10 11 12 13 14 15 16 17 18 19 20 2122 X Y
Transcribed Image Text:30
25
(enjen-d)⁰¹601-
55
20
10
5
O
T
B
DLEC1- OXSR1-
m
XYLB-
+ACAA1 SLC22A13→→ *LOC100128640
MYD88→→
SLC22A14→→ ACVR2B-
-SCN5A
EXOG->
rs6801957
-SCN10A
+SCN11A
WDR48→>
HEIM
- GORASP1
TTC21A->>
--CSRNP1
As shown in the Manhattan plot in previous question, the authors
have identified a single best candidate gene for most loci
identified in their study, but identified two candidate genes for
the locus on chromosome 3: SCN5A and SCN10A. These are
related genes that both encode cardiac sodium channels. The
regional association plot for this locus is shown above, with gene
models in this region shown below the plot. Based on the
information shown here, why did the authors nominate SCN5A
and SCN10A as candidate genes, but not SCN11A, another
cardiac sodium channel gene adjacent to SCN10A? Limit your
answer to 1-2 sentences.
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