Which of the following is NOT a primary method used to regulate the activity of cyclin-dependent kinases (cdks)?   A. Binding to cyclins   B. Binding to a CDK inhibitor   C. Dephosphorylation of a specific amino acid   D. Degradation by a proteasome   E. Phosphorylation on a specific amino acid

Question 5

QUESTION 34 Which of the following events does NOT occur during ERAD (ER-associated degradation)? OA. Chaperone-mediated attempts at protein folding OB. Degradation of misfolded proteins by the proteasome OC. Targeting of mis-folded proteins to the nucleus OD. Repeated attempts at protein folding QUESTION 35 Which of the following statements regarding COPII vesicles trafficking between the ER and the Golgi is NOT correct? OA. Uncoated vesicles fuse with the cis-Golgi. OB. The vesicle enclosed in a COPII coat fuses with the cis-Golgi. OC. The COPII vesicles lose the COPII coat before reaching the Golgi. OD. COPII-coated vesicles bud off from the RER. QUESTION 36 Which phenotype would you expect to see in cells that contain a defective Rab GTPase that cannot be activated on the inner surface plasma membrane? OA. The cell would lack secretory vesicles. OB. No phenotype OC. The cell would have an excess of secretory vesicles within the cytoplasm and defective secretion. OD. The cell would…

QUESTION 1 The Wnt signaling pathway component, Dsh, effects the action of B catenin by: O A. inhibiting the function of axin in the destruction complex O B. blocking GSK-3B from joining the destruction complex O C. stimulating ubiquitination of B catenin O D. causing its release into the cytosol from the plasSma membrane complex O E. causing an increase in phophorylation of B catenin QUESTION 2 PCR can be used to identify the breakage points of mtDNA that are joined to form a mitochondrial genome with a deletion. This technique uses: O A. two primers outside the deleted region; a long PCR extension segment. O B. one primer within the deleted region and one primer outside the deleted region; a long PCR extension segment O C. one primer within the deleted region and one primer outside the deleted region; a short PCR extension segment O D. two primers outside the deleted region; a short PCR extension segment O E. two primers within the deleted region; a short PCR extension segment

Question 25 The inferior surface of a neuron’s plasma membrane at resting membrane potential will have--- A) Negative charge and contains less sodium than outside of the cell B) Positive charge in contains more sodium than outside of the cell C) Negative charge and contains more sodium than outside of the cell D) Positive charge in contains less sodium than outside of the cell The term central nervous system refers to? Please  provide a brief explaination of each one correct or incorrect

Question 2. In the presence of low levels of GTP, microtubules inside a cell will undergo due to A.Catastrophe, instability of the plus end B.Extension, low GTP C.Catastrophe, high GTP D.Rescue, instability of the minus end E.Rescue, instability of the plus and minus ends Multiple Choice

QUESTION 22 Ribosomal RNA: a. none of the above b. acts only as a structural scaffold O C. catalyzes peptide bond formation d. base pairs with DNA

Question 12 Identify the key step in regulation of protein hormone release. O A. Exocytosis B. Signal sequence cleavage O C. Diffusion through the cell membrane D. Kinase activation of biosynthetic enzymes E. Golgi transport

Question one parts A though e a. You have a plan to make the cellular signaling peptide RGD (Arg-Gly-Asp). If you are beginning from the Arginine (Arg) amino acid, which amino acid(s) will require NH2 protection to optimize the synthesis? A) All 3 amino acids will need NH2 protection B) Gly and Asp will need NH2 protection C) Arg and Gly will need NH2 protection D) Only Arg b. Which of the following amino acids will not produce a purple color (indicative of 2 ninhydrin molecules binding) when reacted with ninhydrin? A) phenylalanine B) valine C) proline D) histidine c. If you had a mixture of leucine, arginine, and glutamic acid in a pH of 6 and applied a drop onto paper connected to an electrophoresis apparatus. Which of these would move toward the cathode (-). A) Leucine B) Arginine C) Glutamic Acid D) None of them d. True/False - Dicyclehexvlcarbodiimide is a typical reagent in peptide synthesis for protecting carboxylic acid groups. e. True/False t-butoxycarbonyl dicarbonate…

QUESTION 38 Which of the following pairs is matched INCORRECTLY? a. Autophagy - Mitochondria O b. Cell membrane - important in communication and receiving signals O c. Peroxisomes - breakdown of hydrogen peroxide d. Tay-Sachs disease - failure of lysosomes to digest a particular lipid in brain cells O e. Plasma membrane-selectively permeable barrier