Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- Which of the following statements are true for antigen presentation. a. Antigen presentation means that other cells attach the pathogen first and present it to T cells. b. Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells c. Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface. d. Antigen-presenting cells are phagocytic cells e. Antigen presentation is required for T cell activation f. Cytokines released by macrophages are required for T cell activation g. T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells. h. Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activationarrow_forwardAntibodies Select one: a. are not specific, but act generally. b. are composed of four light and four heavy polypeptide chains. c. play a large role in cell-mediated immunity. d. are produced by both T and B cells. e. have a variable region that binds to a specific antigenic determinant.arrow_forwardNEED ASAP PLSarrow_forward
- You have a patient with abnormally high IgE antibodies. What are two scenarios that might lead to a high level of IgE antibodies? How would you find out which scenario is causing the increase in IgE?arrow_forwardAn MLS has completed an antibody panel using PEG. She cannot exclude anti-Fya, or anti-E. Anti-Kpª and anti-Ja cannot be excluded either but they are low incidence antigens and the MLS is not concerned with those at this time. What would be the next logical step to aid in antibody identification? a. Run the panel again using ficin treated cells b. Run the panel again using 22% albumin for enhancement c. Pay special attention to the strength of the agglutination reactions d. Run the panel again but increase the 37 degree incubation time to one hourarrow_forwardSelect all correct matches: a. Heavy chain / the larger of the two protein chain types found in antibodies b. Hapten / the site on an antibody that binds to antigen c. Gamma globulin / antibodies purified from serum d. Cytokine / a secreted protein that affects immune cell functionarrow_forward
- Explain why each choice (a-d) is correct or incorrect. Allergens differ from antigens because a. Allergens produce an abnormally large immune response to what is an otherwise harmless particle. b. Allergens do not involve the leucocytes, they simple stimulate the inflammatory response. c. Allergens are only active seasonally and are generally harmless to the body. d. Allergens are primarily plant derived while antigens are bacterial or viral in nature.arrow_forwardWhich of the following is an INCORRECT match?arrow_forwardIdentify which of the following statements regarding naive T cells is incorrect. a. Naive T cells have the capacity to survive for many years as nondividing circulating cells in the absence of specific antigen. b. Naive T cells express LFA-1 molecules that change their conformation after encountering a specific peptide:MHC complex. c. Naive T cells exit from lymph nodes using the same route as effector T cells. d. Naive T cells express ICAM-3, which binds to DC-SIGN on dendritic cells with high affinity. e. Naive T cells express high levels of S1P receptors on their surface.arrow_forward
- Why is it important to measure the pharmacokinetics(PK) and metabolism of an antibody drugarrow_forwardDiscuss the role of autoantibodies in three named autoimmune diseases, then discuss how four named monoclonal antibody therapies (biologics) have been used to treat patients with autoimmunity. Use the aid of many diagrams. 2500 words.arrow_forwardWhich ONE of the following flow cytometry results is most likely in a patient with chronic lymphocytic leukaemia? Select one: A.CD11c+, CD25+, CD103+ B.CD5+, CD19+, CD20+ (dim) C.Surface immunoglobulin+, CD5+, cyclin D1+ D.CD10+, CD20+, FMC7+arrow_forward
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