Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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• Whether a mutation is recessive or dominant to wild type
depends on how drastically the protein product is altered
and how sensitive ________ is to the abnormal gene
function.?
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- Wild type genomic sequence of a portion of a gene and the wild type sequence of portion of the protein gene product. The protein sequence only matches partially. ТАT AAA GGG СGA ССА ССТ GсT AАT GGG АСт тTG AGG Tyr Lys Gly Arg Pro Pro Ala Pro Arg Gln Tyr Trp Note: The five amino acids at the amino end of the WT protein match the coding sequence perfectly, but not the six at the carboxyl end. This is for an obvious reason that you should figure out before starting the problem. One of the difficulties with this problem is that you do not have the DNA sequence for the carboxyl end of the protein, but that should not be a problem! And, so far, there are no mutations; nothing unusual, it is just a normal eukaryotic gene!! A mutant is found that has the following protein sequence in that part of the protein: Tyr Lys Gly Arg Thr Cys Ser Premature Stop. What is the likely mutation? between A12 and C13 insert T. between C13 and C14 insert T. A15 -> del. C13 and C14 -> del. G8 -> T. G20 -> A. T21…arrow_forwardMutations outside the coding sequences can modify geneexpression by altering the amount, time, or place of__________ production.?arrow_forwardDynamic mutations are associated with what type of diseases? Genomic imprinting diseases Trinucleotide repeat disease Maternal effect diseases Mitochondrial diseases None of the answers are correctarrow_forward
- Briefly explain how Genome Wide Association Studies (GWAS) are done. Then, using this example of a Manhattan Plot explain what each of the X-axis and the Y-axis signifies in a GWAS.arrow_forwardMy question:arrow_forwardFill in the blank. [x] _________ genes are pairs of genes within an organism’s genome that have diverged from duplication events.arrow_forward
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