Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- A friend asks for help understanding replication for the next biology test. (S)he draws a replication bubble for a DNA molecule being replicated. The origin of replication is shown (0) and newly replicated DNA is shown as gray. Small gray arrows represent okazaki fragments. Solid gray lines represent leading strand. Draw a corrected version of a replication bubble below.arrow_forwardDefine DNA replication/synthesis and semiconservative replication. In addition, describe and/or define the role(s) of each of the following in the process of DNA replication/synthesis: DNA template strand, 5’ and 3’ ends, DNA helicase, DNA polymerase, single-strand binding proteins, topoisomerase, primase, Okazaki fragments, leading strand and lagging strand.arrow_forwardWhich of the following DNA repair processes is known to be "error-prone" (i.e. resulting in incorporation of incorrect nucleotides as part of the repair process)? Mark all the answers that are correct. Base Excision Repair (BER) non-homologous end-joining of double-stranded DNA breaks. O Nucleotide Excision Repair (NER) post-replication repair SO-responsearrow_forward
- How would a scientist, observing a prokaryote and a eukaryote replicating their DNA, be able to distinguish the two? Group of answer choices Prokaryotic replication does not require a primer. Prokaryotic chromosomes have a single origin of replication, while eukaryotic chromosomes have multiple origins of replication. DNA polymerases of prokaryotes can add nucleotides to both 3' and 5' ends of DNA strands, while those of eukaryotes function only in the 5' --> 3' direction. DNA replication in prokaryotic cells is conservative. DNA replication in eukaryotic cells is semi-conservative.arrow_forwardWhich of the following is correct about the function of DNA Ligase? DNA ligase is used on the leading strand and it joins any disconnected strand together O DNA ligase is used on the lagging strand which helps in joining fragments of the strand together O DNA ligase is used on the lagging strand and it aids in correcting mistakes on this specific strand O DNA ligase is used to maintain the replication fork structurearrow_forwardGive typing answer with explanation and conclusionarrow_forward
- Medgie is creating his science fair project on DNA replication. His final display board shows the following. Human DNA Replication Steps Step 1 DNA unwinds in the nucleus Step 2 Complementary base pairs are deleted Step 3 DNA rewinds back together Step 4 The newly made DNA helix is placed in a cell formed in Mitosis According to Medgie's project, which of the following identifies and explains which of the steps is incorrect? O Step 4 is incorrect because not all human cells require DNA. O Step 3 is incorrect because the DNA remains unwound to be transcribed into RNA. Step 2 is incorrect because the complementary base pairs are used as a template, not deleted. Step 1 is incorrect because DNA doesn't unwind in the nucleus, instead it unwinds in the cytoplasm Previousarrow_forwardDNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options: More point mutations will arise in MER-minus yeast. Fewer point mutations will arise in MER-minus yeast as compared with wildtype. Of the total point mutations that…arrow_forwardA drug that inhibits the DNAa protein is added to a culture of E. coli cells. What is the first step of DNA replication that will be impaired by this drug? Group of answer choices Keeping parent DNA strands separated Releasing tension generated by supercoiling Activating the origin of replication Making primers Forming phosphodiester bondsarrow_forward
- Which of the following statements is/are TRUE for DNA Replication? Two daughter DNAs are formed, each one contains an old and new strands. When the (parent) DNA strands unwind, the 3'→ 5' strand is the leading strand while the 5'→3' strand is the lagging strand. Requires dATP, dTTP, dGTP, dCTP and Mg2+ The replisome is the biological machine responsible in replicating DNA.arrow_forwardWhich of the following replication proteins is incorrectly paired with it’s function? DNA polymerase - adds nucleotides to the growing strand Single stranded binding proteins - hold the DNA strands apart while they are being replicated Ligase - enhances separation of DNA strands Topoisomerase - relieves torsional stress due to unwinding by the DNA Primase - synthesizes a short RNA sequence to initiate replicationarrow_forward
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