Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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What would be the effect on ATP production of decreasing the pH inside the mitochondrial matrix? Explain
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- You are studying the enzyme kinetics of enzymes in the TCA cycle. You add a molecule to the mixture that appears to act as a competitive inhibitor of one of the enzymes. At first, you cannot tell which enzyme is inhibited, but you can tell that it is bound to the inner mitochondrial membrane. Can you guess which TCA enzyme you have inhibited and how do you know? Where are other enzymes located in the mitochondrion?arrow_forwardWhat will happen to the proton (H+ions) gradient in the mitochondria if the ATP synthase is blocked?arrow_forwardWhich complexes of the electron transport system are able to catalyze the synthesis of ATP from ADP to Pi?arrow_forward
- propose a mechanism that could allow pyruvate to cross the mitochondrial memebranes to enter the mitochondrial matrixarrow_forwardYou are given a suspension of purified mitochondria that are known to have adequate reserves of NAD+, FAD, and ADP/inorganic phosphate. Assume that the mitochondrial preparation you are working with is free of cytosolic components (enzymes and metabolites) and assume that all the compounds listed below can cross both mitochondrial membranes, When glucose is added to this suspension: a. What is the effect on oxygen consumption by the purified mitochondria? b. Explain your answer above. When citrate is added to this suspension: c. What is the effect on oxygen consumption by the purified mitochondria? d. Explain your answer above.arrow_forwardBoth mitochondria and chloroplasts use a proton gradient to drive ATP synthesis, but in different locations. What is the major structural difference, that is related to the proton gradient, between mitochondria and chloroplasts, and where is ATP generated in each?arrow_forward
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