Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by stepSolved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Acetyi CoA Oxaloncetate CoA NADH Citrate NAD Isocitrate Malate Funiarate NAD co NADH FADH, FAD a- Ketoghutarate Succinate co, NAD+ ATP Succinyl CuA NADH ADP - P For each molecule of glucose (C6H12O6) oxidized by cellular respiration, how many moles of CO2 are released in the citric acid cycle? (see the figure above) а. 2 b. 4 с. 6 d. 0 е. 3arrow_forwardIf oxidation of acetyl-CoA yields 10 ATPs per mole through the citric acidcycle, how many ATPs will be derived from the complete metabolic oxidation of 1 mole of alanine in a mammal? Would the corresponding energyyield in a fish be higher or lower? Why? How much energy would bederived from the metabolic oxidation of 1 mole of isoleucine to CO2, H2O,and NH3? Of tyrosine?arrow_forward[AktivGrid] Draw the product of the reaction of isocitrate catalyzed by isocitrate dehydrogenase in the TCA (citric acid) cycle. Provide the structure in the protonation state found in physiological conditions. 9 H-C-OH 800- -H CH₂ ° Coo of NAD+ dehydrogen isocitrate ase NADH, H*, Drawing CO2arrow_forward
- 9. The equation below depicts the first step of the citric acid cycle. H0 CoA-SH CH-C + 0=C-CO0 HO C-COO citrate s-COA ČH2-COO synthase ČH2 -CO0 Citrate Acetyl-CoA Oxaloacetate AG" = -32.2 kJ/mol a) Explain the chemical conversions that take place during this step. b) Why is this reaction energetically favorable? Explain.arrow_forwardIn 1937, two German biochemists published a paper proposing these reactions as part of glucose oxidation: citrate → isocitrate → α-ketoglutarate →succinate → fumarate → malate → oxaloacetate. Adding succinate, fumarate, or malate to thin slices of tissue increased oxygen consumption, supporting the hypothesis that these molecules are intermediates in the process. However, they were puzzled by the observation that these intermediates were still present in the reaction mixture at the end of the experiment. They had thought that intermediates would be consumed as they were converted to the next molecule in the pathway. What explains the observation that these intermediates were still present? a) The pathway is a cycle, constantly regenerating intermediates as glucose is broken down. b) Succinate, fumarate, and malate are not reactants but catalysts, and catalysts are not consumed in the process. c) Succinate, fumarate, and malate increase metabolism and therefore oxygen consumption,…arrow_forwardWhat four allosteric enzymes or enzyme complexes are responsible for the regulation of the citric acid cycle? Select all that apply. Malate dehydrogenase Fumarase Succinyl CoA synthetase Aconitase a-ketogluatarate dehydrogenase Succinate dehydrogenase Pyruvate dehydrogenase Citrate synthase Isocitrate dehydrogenasearrow_forward
- What is the fate of the radioactive label when each of the following compounds is added to a cell extract containing the enzymes and cofactors of the citric acid cycle and the pyruvate dehydrogenase complex? P.S. A detailed steps explaination would be greatly appreciated. Also, any tips on how to solve such problems if possible? Is there any particular fate that C atoms of the R group for example, have, at the end of the cycle? I usually think of drawing out each step and solving but I believe that there must be a shorter, smarter way to do it and similar questions. Thank you!arrow_forwardalpha-ketoglutarate dehydrogenase will do which of the following: Select one: a. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide b. Succinate is oxidized to become fumarate forming FADH2 c. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH d. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) e. Malate is oxidized to become oxaloacetate forming NADH f. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADH g. Citrate is rearranged to become Isocitrate h. Fumarate is combined with water to become Malate i. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADHarrow_forward
arrow_back_ios
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON