Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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What is the likely function of the cytosolic cAMP in this transduction pathway?
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Transcribed Image Text:H
H₁ H
ATP synthase
UCP1
Beta-3 adrenergic receptor-
H₁
H₁
H
Cytosol
H' H
H
H
H
H
H
H
H
Mitochondria
inner-membrane
-Norepinephrine
G-protein
Fatty acids
Mitochondria
outer-membrane
CAMP
Protein
kinase A
Lipase
ATP
1. Norepinephrine binds the Beta-3 adrenergic receptor.
2. The Beta-3 adrenergic receptor activates a G-protein.
3. The activated G-protein activates an adenylyl cyclase.
4. The activated adenylyl cyclase converts ATP into CAMP.
5. CAMP activates the protein kinase A.
Adenylyl cyclase
Triacylglycerol
In brief, the transduction pathway that regulates the activation/inhibition of UCP1
under the control of norepinephrine is as follows:
6. The protein kinase A activates a lipase through phosphorylation.
7. The activated lipase hydrolyzes triacylglycerol (the main constituent of body
fat) into fatty acids.
8. Fatty acids activate UCP1.
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