What is the difference between a proto-oncogene and a tumor suppressor gene?  How can mutations in these genes lead to cancer

Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb?  If so, how…

A: The process by which a cell gives rise to two identical daughter cells is referred to as cell…

Q: The protein p53 is activated when the cell's DNA is damaged. p53 helps to arrest the cell cycle in…

A: Cell division is controlled by a protein that is encoded by a tumor suppressor gene. Uncontrolled…

Q: Why is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene…

A: Uncontrolled cell division in the cells may result into the tumor formation. Sometimes the cells may…

Q: The C-myc gene is a proto-oncogene which is highly expressed in breast tissue and appears to cause…

A: Answer.) :- The ChIP data provided involves key molecular components and factors associated with…

Q: Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb?…

A: Cell division is a process through which a cell produces two identical daughter cells. Cell division…

Q: How can researchers pinpoint the particular driver mutations most responsible for the cancer…

A: The development of cancer is an evolutionary process at the cellular level. Several mutations…

Q: Compare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes.…

A: Genetic changes are the primary cause of cancer, an incredibly complicated and multidimensional…

Q: Which of the following mutations is MOST likely to cause cancer? A) a mutation that causes a cyclin…

A: Introduction- Cancer is a caused by the disturbances in the  controls which regulate cells and this…

Q: Explain the role of epigenetic alterations in cancer ?

A: Genes are the hereditary unit in an organism and are passed on from the parental generation to the…

Q: How interfered regulatory machinery results in production of tumor?

A: Eukaryotes have well-organized nucleus. prokaryotes are devoid of nuclear arrangements. genome…

Q: How can cancer arise from stem cells?

A: Stem cells are unique human cells and can grow into several cell types. This can vary between cells…

Q: Which mutations are more common in cancers,  growth promoters  or suppressors and why?

A: Cancer is a complex group of disease affecting a wide range of cell and tissues. It results from…

Q: How can a mutation in a tumor-suppressor gene contribute to the development of cancer?

A: Tumor-suppressor genes are like any other normal genes whose functions include slowing down cell…

Q: Describe the differences between point mutations, chromosomal translocations, and gene amplification…

A: Cancer is a disease that is associated with the uncontrolled division of cells and invasion of…

Q: What genes are involved in cancer?

A: Genes Involved In Cancer --- Genes  and Their Characteristics -- Genes are made up of pieces of DNA…

Q: According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop.…

A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…

Q: Which of the following is an example of a proto-oncogene? 1) cell cycle inhibitor 2) tumor…

A: Oncogene The gene that are cancerous and divide cell abnormally.

Q: How do normal cells protect themselves from accumulating mutations in genes that could lead to…

A: Studies reveal that the p53 protein instructs cells to under-go apoptosis when mutations in the DNA…

Q: Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do…

A: Oncogene is a type of gene having the ability which can develop a cell to a tumor cell when…

Q: The p53 gene is a tumor-suppressor gene while Ras is a proto-oncogene. Mutation in either one can…

A: Tumor suppressor genes are the genes that are involved in various checkpoints in the cell cycle,…

Q: The "initiation" stage of cancer refers to:     a)  The stage where DNA is mutated, and permanent…

A: Introduction :  Cancer is defined by the following characteristics: • Uncontrolled…

Q: Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger…

A: Hematologic childhood cancer can develop in any part of the body, including the blood and lymph…

Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?

A: Normal cell growth in body is controlled by -  1. Protooncogene or cellular oncogene - Protooncogene…

Q: How oncogenes contribute to cancer?

A: Cancer:       It is a disease where cells divide abnormally and damage other cells. There are…

Q: Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene…

A: An oncogene helps in control cell division and  contributes to cancer progression whereas a tumor…

Q: Which of the following chromosomal changes would be LEAST likely to cause the development of cancer?…

A: Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably.…

Q: How does the epithelial-to-mesenchymal transition (EMT) contribute to tumorigenesis and disease…

A: Epithelial-mesenchymal transition (EMT) could be a method within which epithelial cells acquire…

Q: The following are drugs that act as anti-tumor agents and are often used as part of chemotherapeutic…

A: Drug - adriomycin, target organ - intercalates between DNA base. MECHANISM OF ACTION:Doxorubicin…

Q: how do tumor suppressor genes and proto-oncogenes causes cancer?

A: Tumor suppressor genes- These are the normal genes and they are responsible for regulating cell…

Q: How tumor-suppressor mutations contribute to cancer?

A: Cancer - Cancer is a type of disease in which cells divide in an uncontrolled manner. The cells…

Q: A microarray is a technique used to develop a profile of the messenger RNA being transcribed by…

A: The tumor suppressor genes are the genes that code for a protein whose function is to suppress the…

Q: How does the normal p53 protein inhibit cancer development?

A: Tumor-suppressor genes code for proteins that repair damaged DNA (preventing a cell from turning…

Q: What are the major differences between a tumor initiator (e.g., DMBA) and a tumor promoting agent…

A: Cancer is a disease in which cells, almost anywhere in the body, begin to divide uncontrollably…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.