What are proto-oncogenes, oncogenes, and tumor suppressor genes and what is their involvement in cancer?

Q: Distinguish between proto-oncogenes and tumorsuppressor genes.

A: The proto-oncogenes are those genes, which promote cell cycle and inhibit apoptosis of the cells.…

Q: The Bcl-2 protein was initially discovered via its ability to contribute to progression of B-cells…

A: Cancer is a disease caused by abnormal cell division.

Q: How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the…

A: Epigenetics is the study of various alterations in an organism occurred because of certain gene…

Q: Why are some chromosomal regions amplified/deleted in a specific manner in certain tumor types?

A: Chromosomal amplification: Chromosomal amplification can be explained as the increase in the amount…

Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…

A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…

Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…

A: False statement about tumor suppressor genes.

Q: Why is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene…

A: Uncontrolled cell division in the cells may result into the tumor formation. Sometimes the cells may…

Q: Cancer cells generally have missense mutations in p53 gene, resulting in truncated p53 normally…

A: A normal cell is converted into a cancer cell when the there is deactivation of the tumor suppressor…

Q: What are the normal functions of the BRCA1 tumor suppressor gene?

A: The BRCA1 gene codes for the protein that causes breast cancer type 1. BRCA1 is a human tumour…

Q: Explain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause…

A: A tumor suppressor gene is normally a cellular gene that regulates the cell proliferation or DNA…

Q: why EGFR play a role in CRC and other cancer?

A: EGFR : It is epidermis growth factor receptor.  CRC:  Colorectal cancer. EGFR : It is one of the…

Q: Compare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes.…

A: Genetic changes are the primary cause of cancer, an incredibly complicated and multidimensional…

Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…

A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…

Q: Explain why mutations in tumor suppressor genes are recessive (both copies of the gene must be…

A: Mutation in an organism is defined as a permanent alteration of “nucleotide sequences”. The…

Q: How can oncogenes lead to cancer?

A: Oncogenesis is a complex, multifactorial process by which normal cells turn into malignant cells.…

Q: What is the difference between an oncogene and a tumor-suppressorgene? Give two examples of each…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: "In the cellular regulatory pathways that control cell growth and proliferation, the products of…

A: Normal genes that are changed to become oncogenes are known as proto-oncogenes. They carry out a…

Q: How can a mutation in a tumor-suppressor gene contribute to the development of cancer?

A: Tumor-suppressor genes are like any other normal genes whose functions include slowing down cell…

Q: Cancer is caused by many different types of gene mutations. Some mutations are in proto-oncogenes,…

A: Cells split into new cells so that the body uses them and cancer starts with this wonderful…

Q: What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to…

A: Cancer is group of diseases which are characterized by abnormal and unstoppable growth of cell and…

Q: Compare the usual functions of proteins encoded by proto-oncogeneswith those of proteins encoded by…

A: Proteins are macromolecules formed by the long chain of amino acids. They are involved in a wide…

Q: Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do…

A: Oncogene is a type of gene having the ability which can develop a cell to a tumor cell when…

Q: The palladin gene, which plays a role in pancreatic cancer (see theintroduction to this chapter), is…

A: A disease is an abnormal condition that negatively impacts the structure and function of an…

Q: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in…

A: Proto Oncogenes are the genes that cause cancer when there are alterations in them. Several factors…

Q: What are Ras protein and p53?

A: Different proteins control different mechanisms in the body in inducing the cell growth, cell…

Q: The p53 gene is a tumor-suppressor gene while p634  gene is an oncogene. Mutation in either one can…

A: Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts…

Q: is a normal cellular gene that through a A an oncogene. OA) proto-oncogene...loss-of-function OB)…

A: An oncogene is a cancer-causing gene that has been mutated. A proto-oncogene is a type of oncogene…

Q: Why don’t all loss-of-function mutations that are recessive at the cellular level behave as…

A: Loss of function mutation is otherwise known as inactivating mutations. This type of mutation is…

Q: Relatively few inherited forms of cancer involve the inheritance of mutant oncogenes. Instead, most…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: Prompts Šubmitted Answers protect cells from uncontrolled proliferation Gain of function Choose a…

A: Introduction: Sporadic cancer is caused by a genetic mutation that occurs during one person's…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.