Vitamin A in vision Vitamin C in collagen formation Vitamin K in blood clothing
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Explain the role of the following
- Vitamin A in vision
- Vitamin C in collagen formation
- Vitamin K in blood clothing
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Solved in 2 steps
- Draw the structure of phosphatidylcholine at pH 7 with the moiety on R₁ as 14:0 (C14) and R₂ as 12:2cis,cis-A6,9. Put an X on the bond cleaved by Phospholipase C.Give the name and structure of: Ceramide Shiphingomyelin GangliosideList two classes of compounds derived from arachidonic acid. Suggest some reasons for the amount of biomedical research devoted to these compounds.
- About cardiotonic glycosides, based on a digoxin structure in the image: Classify the α,β-unsaturated lactone present in digoxin. What is the mechanism of the pharmacological action of digoxin, explain in detail?*H3N -Č-H CH2 он Tyrosine a. Draw the structures of tyrosine as different pH values. Please refer to the lecture notes for the pKa values b. Identify the structures that exist at pH 2 c. Solve for the plGiven lecithin, sphingomyelin, cephalin, phosphatidylcholine which of the following does not contain glycerol as a backbone?
- Using the Nernst equation, calculate the equilibrium potential for Ca2 and for C1 from the following sets of data: a. Given [ Ca2+ ]0=1mM,[ Ca2+ ]i=100nM, find Eca2+ b. Given [ Cl- ]0=110mM,[ Cl- ]i=100mM, find Eclα-D-Galactopyranose rotates the plane of polarized light, but the productof its reduction with sodium borohydride (galactitol) does not. Explain thedifference.The primary structure of b-endorphin, a peptide containing 31 amino acids synthesized by the body to control pain, is shown here: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr- Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu What fragments are obtained as a result of treatment withcyanogen bromide?
- The primary structure of b-endorphin, a peptide containing 31 amino acids synthesized by the body to control pain, is shown here: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr- Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu What fragments are obtained as a result of treatment with trypsin?Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).Estimate the binding affi nity of a ligand for its receptor from the followingdata:
