THE CHROMOSOMAL INSTABILITY PATHWAYS IN COLON CANCER Provide exmaples of genes  give evidence

Q: Give some Examples of Drugs That Specifically Target Proteins Mutated or Abnormally Expressed in…

A: Genes have the overall control on a cell. The, growth, replication, etc. of a cell is coordinated by…

Q: Gain-of-function mutations could contribute to cancer progression if the mutant gene is,   a) p53…

A: Loss-of-function mutations are changes to a gene that results in a decrease or loss of the gene’s…

Q: Can we identify general featurescommon to all cancer cells—such astheir production of misfolded,…

A: Cancer can be of different types depending upon the type of cells, organ affected, and stage. The…

Q: Why are some chromosomal regions amplified/deleted in a specific manner in certain tumor types?

A: Chromosomal amplification: Chromosomal amplification can be explained as the increase in the amount…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: What is meant by the "two-hit" model of cancer development? Describe this theory in detail and…

A: Two-hit hypothesis : The "two-hit" hypothesis or model was first proposed by geneticist Alfred…

Q: How might genomic information be helpful for the effective use of imatinib mesylate (Gleevec) in…

A: Imatinib mesylate is a drug used for the treatment of myeloid leukemia that is caused due to…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Medical technology has advanced significantly over the course of many centuries. According to…

Q: explain and analyse each gene mutaition  in the CIN, MSI, CIMP pathways and what are the causes of…

A: Colorectal cancers develops via an ordered series of events that initiates with the transformation…

Q: Describe three common ways that tumor-suppressor genes aresilenced.

A: Tumour suppressor genes are genes that can decrease the rate of cell division and growth. In the…

Q: Explain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause…

A: A tumor suppressor gene is normally a cellular gene that regulates the cell proliferation or DNA…

Q: why EGFR play a role in CRC and other cancer?

A: EGFR : It is epidermis growth factor receptor.  CRC:  Colorectal cancer. EGFR : It is one of the…

Q: Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic…

A: Cancer is a major disorder and it causes development of abnormal cells & they divide…

Q: (a) Identify both the cellular component and the location of the component that is responsible for…

A: Luciferase reporter produces luminescence. If cells contain a luciferase vector, the luminescent…

Q: Describe three popular methods for silencing tumor-suppressor genes.

A: Introduction Tumor suppressor genes are those that slow down the division and development of cells.…

Q: Mutations in the RB gene are often associated with cancer. Explain how a mutation that results in a…

A: The cell cycle is the series of stages that allow the cell to pass from one cell division to…

Q: Please explain the role of gene expression in the process of a stem cell differentiating into a…

A: Gene expression is the process of central dogma where protein is formed from DNA. Stem cells have…

Q: Explain how chromosome deletions, inversions, and translocations cancause cancer.

A: Cancer is a disease which is caused by the uncontrolled growth of the cells, without regulation of…

Q: What is the difference between an oncogene and a tumor-suppressorgene? Give two examples of each…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Explain about the Cancer-causing gene formed by a mutation in a proto-oncogene ?

A: In genetics, the mutation is defined as the changes or alteration in the DNA sequences which result…

Q: illustrate some of the molecular mechanisms leading from loss-of-function mutations in…

A: Tumor suppressing genes also known as Anti - oncogenes are the  regulatory genes which regulates…

Q: Why would elevated levels of PSA be suggestive of prostate cancer given what you know about cancer?…

A: The prostate gland is situated below the urinary bladder and is responsible for the production of…

Q: Describe the differences between point mutations, chromosomal translocations, and gene amplification…

A: Cancer is a disease that is associated with the uncontrolled division of cells and invasion of…

Q: What is/are the role/s of molecular techniques in understanding cancer? Cite some references from…

A: In cancer, cells grow abnormally. Cancer is not one disease. It is a group of diseases. The…

Q: compare and explain which genes from these from the CIN,MSI,CIMP pathways have the strongest links…

A: Colorectal cancer (CRC) is one of the most frequent types of cancer worldwide. Colorectal cancer…

Q: Compare the usual functions of proteins encoded by proto-oncogeneswith those of proteins encoded by…

A: Proteins are macromolecules formed by the long chain of amino acids. They are involved in a wide…

Q: Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do…

A: Oncogene is a type of gene having the ability which can develop a cell to a tumor cell when…

Q: xplain the way in which change in the state of differentiation of Acute Promyelocytic Leukemia (APL)…

A: Introduction: White blood cells can develop a malignancy known as acute promyelocyte leukemia (APL…

Q: How does the multistep model of cancer explain the observation that sporadic cases of retinoblastoma…

A: Disease is a sickness or illness characterized by specific symptoms and signs. Cancer is a…

Q: Even though cancer genomes are overall hypomethylated, explain in detail some genes are…

A: introduction: The study of changes in gene expression and DNA sequencing between cancer cells and…

Q: ''In the cellular regulatory pathways that controlcell growth and proliferation, the products of…

A: Cell regulation involves a complex mechanism of different cell signaling pathways that work in a…

Q: Explain the difference between proto-oncogene and tumor suppressor mutations in terms of its…

A: Cancer is a medical condition that is characterized by the growth of tumors in the body of an…

Q: Briefly describe the structural variability of cancer genomes.

A: The loss or drift may result in the occurrence of cancer in breast cancer. Breast cancer is define…

Q: Explain in general what is meant by a proto-oncogene and how they are involved in the formation of a…

A: Proto-oncogenes are a bunch of normal genes present in a cell. They have the necessary information…

Q: Explain whether a cancercausing mutation in a tumorsuppressor gene, such as p53,is more likely to be…

A: Tumor suppressor gene regulates a cell during the cell division and replication. If cells grows…

Q: Please explain the regulatory role of Bcl-2 family proteins in cell death?

A: BCL-2 family proteins are the controllers of apoptosis, yet additionally have different functions to…