The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the Uo was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculations
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- Calculate the oral loading dose (LD) of digoxin for Miss Jones who weighs 60 kg. The desired plasma concentration (Cp) is 1.5 mcg/L, volume of distribution (Vd) is 7.3 L/kg, the salt factor (S) is 1 and bioavailability fraction (F) is 0.7.Give your answer to the nearest whole number of micrograms.The equation below can be used:Loading Dose = Cp desired x VdS x FTreatment with the drug carvedilol for heart failure is initiated with a dose of3.125 mg twice daily and then increased every two weeks with twice-daily doses of6.25 mg, 12.5 mg, and 25 mg. How many of each of these tablet strengths shouldbe dispensed for this protocol?The biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.
- KCI for injection contains 40 mEq in 20 mL. An order requires 15 mEq, how many mL are needed?Digitalis, a drug used to control atrial fibrillation in patients is to be delivered to have a the drug amount to 20.0 μμg/kg body weight (2.205 pounds = 1.00 kg). The drug concentration must be carefully controlled and accurately measured or the patient may die from too low of concentration from heart complications or too high concentrations of fatal overdose. Calculate the mL of digitalis needed to treat a 160.0 pound patient using 0.800 mg/mL digitalis solution.To calculate the total amount of drug in a solution How much sodium bicarbonate is there in a 200 mL infusion sodium bicarbonate 8.4% w/v?
- The results observed in a patient admitted to an emergency department with confusion and oliguria were reviewed (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 7.2 mmol/L 18.5 mmol/L 256 μmol/L 319 IU/L 32 IU/L 42 g/L 13 μmol/L 2.47 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (a) What is the electrolyte abnormality in this patient? (b) What do the data suggest? (c) What action should you take? (5-42) (35-50) (<17) (2.12-2.62) The sample was not visibly haemolysed and was centrifuged and analysed in the labora- tory within one hour of being collected.The drug dosage for the patient is calculated using a BSA of 1.9m2. If the order is 15mg per m2, how many milligrams is the desired dose?When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/mL) observed over time (hr) can be described by the following equation: C = 3.6e-0.105t C= 3-6e AUC 36 6 -0.105t 5. Calculate AUC(0-0) 0-105 = 34.28 6. What is the volume of distribution? Dose 100 VD= Co 3-6 7. Calculate the clearance of this drug. CI = KXVD CI = 0•105 x 27-8 %3D %3D Cl=2.9 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL?