A 2-year-old child presents with metabolic acidosis after ingesting an unknown number of flavored aspirin tablets. At presentation, her blood pH was 7.0. Given that the pKa of aspirin (salicylic acid) is 3, calculate the ratio of its ionized to un-ionized forms at pH 7.0.
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- Normal arterial pH is 7.35 to 7. 45. Both metabolic and respiratory alkalosis have pH more basic compare to the normal arterial pH. The difference is 0.5 units. What is pH value in alkalosis? Niemann-Pick type C disease is a progressive neurological disease; symptoms include unsteady walking with uncoordinated limb movements, slurred speech, a difficulty in swallowing, epilepsy and tremor. This condition is due to the abnormal functioning of a lysosome. State the normal functions performed by this organelle.A buffer solution contains an equal concentration of weak acid HX and its conjugate base ion X™. The ionization constant Ka of HX is 2.2 x 10-8. What is the pH of the buffer?The results observed in a patient admitted to an emergency department with confusion and oliguria were reviewed (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 7.2 mmol/L 18.5 mmol/L 256 μmol/L 319 IU/L 32 IU/L 42 g/L 13 μmol/L 2.47 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (a) What is the electrolyte abnormality in this patient? (b) What do the data suggest? (c) What action should you take? (5-42) (35-50) (<17) (2.12-2.62) The sample was not visibly haemolysed and was centrifuged and analysed in the labora- tory within one hour of being collected.
- Refer to the following titration curve below: 13 12 11 10 7 5 4 3 2 8 10 12 14 16 18 20 22 24 26 28 30 Volume of Titrant / mL Unknown Acid 0.10 mol/L - titrant = NaOH 0.1 mol/L How many buffering regions are present in the titration curve of the amino acid?Calcium carbonate (CaCO₃(s)) is an important building material (limestone) and a quick cure for acid indigestion (TUMS). Ksp = 8.7x10⁻⁹ for CaCO₃(s). What, if any, is the effect of lowering the pH (as occurs in acid rain and acid indigestion) on the solubility of CaCO₃(s). (hint: use Le Chatelier's principle) A) there is no effect from lowering pH on CaCO₃(s) solubility B) lowering pH increases the CaCO₃(s) solubility C) additional information is required to determine the outcome D) lowering the pH lowers the solubilityGeneral Blood Urine BP: 95/58 pH: 7.1 Odor: "fruity acetone" HR: 110 bpm Glucose: 345 mg/dl pH: 4.3 Ketone bodies: 22 mg/dl Glucose: Strongly positive Blood alcohol: 110 mg/dl 4. Explain how the pH of Mr. Bouchard's blood and urine is related to the ketone bodies measured in each of these fluids. 5. Provide a possible "alternative" explanation for Mr. Bouchard's erratic behavior and high blood alcohol concentration. Think outside the box. 6. What metabolic disease do you suspect Mr. Bouchard suffers from?
- The pH of human blood is buffered at 7.35 to 7.45. If the [OH-] of the blood sample is 6.3x10-6, calculate its pH value. Is the patient’s pH within the range? Or is experiencing acidosis or alkalosis condition?A patient is prescribed 0.151 g of Lidocaine intravenously. The lidocaine is available as a 12 mg/mL solution. How many mL must be administered?Creatinine, C4H7N3O, is a by-product of muscle metabolism, and creatinine levels in the body are known to be a fairly reliable indicator of kidney function. The normal level of creatinine in the blood for adults is approximately 1.0 mg per deciliter (dL) of blood. If the density of blood is 1.025 g/mL, calculate the molarity of a normal creatinine level in a 10.0 mL blood sample.
- amino glycine pka is 2.4, 9.8 Calculate the most effective buffering range. if there is two pka, since there are 2 buffer region, is the buffering range 1.4~3.4 and 8.8~10.8? i would like to know the correct answer and detailed solution/reason.Gout is caused by an error in metabolism that leads to abuildup of uric acid in body fluids, which is deposited as slightlysoluble sodium urate (C₅H₃N₄O₃Na) in the joints. If the extra-cellular [Na⁺] is 0.15 Mand the solubility of sodium urate is0.085 g/100. mL, what is the minimum urate ion concentration(abbreviated [Ur⁻]) that will cause a deposit of sodium urate?The glass electrode used in commercial pH meters gives an electrical response proportional to the concentration of hydrogen ion. To convert these responses to a pH reading, the electrode must be calibrated against standard solutions of known H+ concentration. Determine the weight in grams of sodium dihydrogen phosphate (NaH2PO4 · H2O; FW 138) and disodium hydrogen phosphate (Na2HPO4 ; FW 142) needed to prepare 1 L of a standard buffer at pH 7.00 with a total phosphate concentration of 0.100 M . See Problem 24 for the pKa values of phosphoric acid.