Calculate the oral loading dose (LD) of digoxin for Miss Jones who weighs 60 kg. The desired plasma concentration (Cp) is 1.5 mcg/L, volume of distribution (Vd) is 7.3 L/kg, the salt factor (S) is 1 and bioavailability fraction (F) is 0.7. Give your answer to the nearest whole number of micrograms. The equation below can be used: Loading Dose = Cp desired x Vd S x F

Calculate the creatinine clearance for Lola, a 69 year old woman who weighs 66kg and has a serum creatinine of 125micromoles/L. Round your answer to 2 decimal places Cockroft Gault equation: [ X (140-age) x (weight in kg)] / serum creatinine (in micromole/L) Where X = 1.04 for females and X = 1.23 for males

Acute lymphatic leukemia can respond well to methotrexate given 2 1/2 mg per kilogram every 14 days by IV rounding to the nearest whole number. What would be the appropriate dosage of methotrexate to administer biweekly to a patient weighing 110 pounds?

Please show dimensional analysis to solve

The antibiotic A is administered as a 1.0 g IV-bolus to a 34 years old male subject.  The following plasma concentration data were collected:     Time (hr) Concentrations (mg/L) 0.2 21.51 0.5 17.18 1 12.26 1.5 8.88 2 6.63 3 4.08 4 2.78 8 1.02 12 0.45 24 0.04   Calculate the following parameters (use Excel and the curve stripping method):   PARAMETER VALUE UNITS Elimination half-life (b)     Elimination half-life (k10)     Distribution rate constant     V1     Vss     Clearance     AUC

Jyan is 4 months pregnant and requires an IV infusion of magnesium sulfate heptahydrate at a rate of 5 g/hr for 5.3 hours. Magnesium Sulfate Concentrated Injection (2.465 g magnesium sulfate heptahydrate (MgSO4.7H₂O MWt = 246.5) in each 5 mL ampoule) is to be diluted with 5% w/v glucose solution to a concentration of 20 %w/v for infusion. What volume of 5% w/v glucose solution is required? (Whole number answer.)

A 10-week-old child suffered from a salt-wasting crisis. His adrenal glands were enlarged and other organs were normal size. The child is phenotypically female, karotyping showed that the child is 46XY. The biochemical profile shows as: - sodium of 109 (reference range: 134-147) - potassium of 6.1 (reference range: 3.5-5.0) - pregnenlone of 0.002 (reference range: 0.3-1.5) - renin activity of 38 (reference range: 0.5-3.5) - 17-OH pregnenolone of 0.01 (reference range: 6.8-93.5) - ACTH of 1960 (reference range: 0.5-3.5) The cholesterol esters in the adrenal glands accumulated and the concentration of ∆4-androstenedione was not detectable. Also, the enzymes in the steroid biosynthesis did not have detrimental mutations. The child was given treatment with glucocorticoid and mineralocorticoid. Question: a) Which protein is deficient in this case and explain the rationale.

The order is for 1000ml of 5% D/W, 1000ml of Ringers Lactate, 500ml of NS to run over a 36 hour period. The drop factor is 15gtt/ml. How many gtt/min will you administer? using dimensional analysis and show work

Other Math 1300mL N/Saline 0.9% is running at a 6 hourly rate, which commenced at 1500hrs. At 1630hrs the doctor requests for the remaining volume to be run over 3 hours. Calculate the mL per hour for the remaining volume.

Your 64YO 152lb, 5ft 8in female patient daignosed with advanced bladder cancerhas been prescribed ifosamide 1500mg/m2/day IV for 5 days. You calculate the BSA using the Mosteller method as being 1.82m2. Ifosfamide is available in 60mL vials containing 3g of drugs. How many mL will you administer each day?