The three amino acids "DRY" in loop I2 are required for protein targeting. What is the name of this kind of sequence, and what is its function?

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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The figure  from Moore (2020) shows a G protein-coupled receptor in a membrane. Note that "out" means outside the cell and "in" means facing the cytoplasm.

  1. The three amino acids "DRY" in loop I2 are required  for protein targeting. What is the name of this kind  of sequence, and what is its function?
  2. What protein targeting sequence is no longer included in this diagram? Why?
  3. The sequence "QXXNK" (where X is any amino acid) found in loop I3 has been identified based on its enzymatic activity. What is this activity?
  4. What particular domain would you expect to find in either Loop E1, E2, or E3? 
  5. The gene that codes for this protein is a member of  a family of genes that has arisen over evolutionary time. If you compared several of the genes in this family, would you expect their sequences to be most homologous (similar) in the region you describe in #3 above or #4 above? Why?

 

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