$HOT! a. If the disease were X-linked recessive, what would be the probability that a male child born to Il- 3 and II-4 will be affected? Why? (Note: we already know the child is male.) b. If the disease were autosomal dominant what would be the probability that a male child born to II-3 and II-4 will be affected? Why? (Note: we already know the child is male.)

A. Look at the pedigree, and DISREGARD individual II-8 for the moment. Is the pattern of inheritance of Unetan syndrome dominant or recessive?  You may assume that the gene is FULLY-PENETRANT in this family.  Please give two specific reasons that support your conclusion.   B. Now, looking at BOTH the pedigree AND at the Southern blot, is this trait autosomal, X-linked, or Y-linked? Please give two specific reasons that support your conclusion. Once again, disregard II-8 for the moment. One of your two reasons must refer specifically to evidence present in the Southern blot.   C. Define the gene alleles associated with Unetan syndrome. Your alleles MUST be consistent with the pattern of inheritance, AND your genetic notation must be consistent with that used throughout the course. Unetan syndrome allele:  ________        Normal allele: ________

Fragile X syndrome why is interesting Fragile X syndrome  What are the symptoms or characteristics of this disorder or trait?  What is the prevalence of the trait or disorder? What are the main genetic factors? s the genetic cause of this disorder or trait known? What gene(s) have been proven to be involved? Or, if not known, what genes are thought to be involved? Is it caused by a single gene? polygenic? Multifactorial? Devote a few paragraphs to this   This could be one of the longest parts of the paper, if you choose to focus on this. If multiple genes are thought to be involved, discuss the specific role of at least one of them in depth  (if known). Is the gene you’re discussing thought to play a major or a minor role in the phenotype? What chromosome is it on? What protein does it code for, and how might the protein possibly contribute to the phenotype? If no genes have yet been identified, indicate this, and devote at least one paragraph to any current efforts to determine which…

Consider two genes. The first one is autosomal with dominant allele A and recessive allele a in the population.The second gene is on the X chromosome with dominant allele R and recessive allele r. Recall that the male Y chromosome has no gene alleles.Match the mode of inheritance (MOI) with the sentence that best describes it.