The diagram shows the relative activity of a proto-oncogene and a tumor supressor gene in a normal cell, as well as the activity in four other cells. Normal cell A в D tumor suppressor gene proto-oncogene Which of these cells would be expected to be cancer cells? cell B cell D cell C cell A
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- Which one of the following events is unlikely to beassociated with cancer?a. mutation of a cellular proto-oncogene in a normaldiploid cellb. a chromosomal translocation with a breakpointnear a cellular proto-oncogenec. deletion of a cellular proto-oncogened. mitotic nondisjunction in a cell carrying a deletionof a tumor-suppressor genee. incorporation of a cellular oncogene into a retroviruschromosomeg protein D. Growth factor receptor ng Tool 0 Q ing C. Growth factor-binding protein D. Growth factor receptor E. Transcription activator A child with retinoblastoma is found to have a 13q14 deletion. The Rb gene, which resides at this locus, produces which kind of tumor-associated protein? A. Cell cycle regulator B. Growth factor ㅂ분 요 9 12 W □ @ 2 C Edit in Paint 8 60 8 FocusProto-oncogenes can be converted to oncogenes in a numberof different ways. In some cases, the proto-oncogene itselfbecomes amplified up to hundreds of times in a cancer cell.An example is the cyclin D1 gene, which is amplified in somecancers. In other cases, the proto-oncogene may be mutatedin a limited number of specific ways, leading to alterations inthe gene product’s structure. The ras gene is an example of aproto-oncogene that becomes oncogenic after suffering pointmutations in specific regions of the gene. Explain why thesetwo proto-oncogenes (cyclin D1 and ras) undergo such differentalterations to convert them into oncogenes
- Why is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene (limit 3-4 sentences)?Which of these events do you think is likely to promote tumorigenesis in affected cells? Group of answer choices DNA methylation of the promoter region of a tumor suppressor gene Hypermethylation of transcription factors that antagonize Wntsignaling Open chromatin in the region of of DNA harboring an activating mutation of beta-catenin All of these1. For each of the following genes, categorize them as a tumor suppressor gene or a protooncogene. Please explain each choice. Gene Proto-oncogene or tumor suppressor gene? Explanation Bcl-2 Rb Ras APC p53
- All but which of the following best explains the advantage of cancer cells expressing PKM2 over PKM1? OPKM1 has lower activity PKM2 allows for accumulation of glycolytic intermediates Serine is a more potent allosteric effector of PKM2 Higher serine levels lead to increased activity of PKM2 O Odetermine which statements is either tumor supressor or proto oncogeneWhich one of these is a tumor suppressor gene? myc erbB O Rb Gasp
- Of the following choices a loss of function mutation would most lukely contribute to cancer onset if the mutant gene codes for a : telomerase tumor suppressor protein ATP synthesis enzyme RNS binding proteinA cell picks up mutations that allow it to move past the G1 and G2 checkpoints even if its growth factor is not present, These mutations a tightly to other cells and the extracellular matrix. As a result, this cell would .. O die O form a benign tumor form a malignant tumor that metasticizes O form a mass of normal tissueChemotherapeutic agents can promote apoptosis in cancer cells by these mechanisms except; Group of answer choices Downregulating MCL1 expression Increasing BCL-2 expression Increased p53 expression Increased BIM (BH-3) expression