Suppose a GWAS investigation found a particular LDblock to be associated with people’s preference forchocolate or vanilla ice cream. How could you identify the specific gene within this region of the genomewhose alleles help determine this preference?

Q: Explain one experimental strategy for determining the functional role of the mouse HoxD-3 gene.

A: HoxD-3 gene basically functions in the process of morphogenesis and belongs to the category of…

Q: What is open reading frame? How frame shift mutation can be happened? Explain with example.

A: The branch of science that deals with the study at the DNA and gene levels are termed genetics. It…

Q: n

A: A mechanism for regulating gene expression in bacteria is lactose induction. It includes turning on…

Q: Transformation is a process in which bacteria take up new DNA released by dead cells and integrate…

A: An operon is defined as a group of genes that have a common promoter and regulator and also…

Q: Name the common and rare alleles found in the human population of the TAS2R38 gene

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Q: Price et al. (1999. J. Bacteriol. 181: 2358–2362) conducted a genetic study of the toxin transport…

A: Missense mutation- When one or more amino acids are replaced by the other amino acid.

Q: name and briefly describe two methods you could use to identify the changes in DNA sequence found in…

A: DNA mutations can have a wide range of consequences, including the development of genetic disorders,…

Q: central dogma

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Q: You are analyzing cells that express a fusion gene encoding a FLAG-tagged protein of interest. Upon…

A: Each DNA strand possesses one 3' end and one 5' end. The end which consist of a free amino group is…

Q: What provides a convenient bridge between the low resolution of a karyotype and the ultra-high…

A: Introduction  Cytology refers to the study of cell such as cell morphology, physiology etc. As we…

Q: Researchers have identified a gene (FR) responsible for watermelon resistance to infection by Dacus…

A: Any abrupt changes in DNA or RNA nucleotides that may or may not be responsible for the changes in…

Q: Explain how the technique of replica plating supports the randommutation theory but conflicts with…

A: Mutation is defined as a change or alteration in the nucleotide sequence which in turn alters the…

Q: Explain the Comparison of the regions of human NF1 protein and S. cerevisiae Ira protein that shows…

A: Huge amounts of sequences of DNA have already been determined. The pace at which fresh sequences are…

Q: You sequence a gene in Drosophila melanogaster and D. simulans. You observe 5 non-synonymous…

A: Gene sequencing is used to determine the nucleotide order in a DNA molecule that makes up the…

Q: Based on the NCBI Blastp and reciprocal analysis, are there any mutations to suggest that mus…

A: In thе contеxt of tеsting thе human FGFR3 gеnе in Mus musculus, NCBI Blastp and rеciprocal analysis…

Q: Among different species, describe three distinct mechanisms foraccomplishing dosage compensation.

A: Dosage compensation is a mechanism by which organisms equalize the gene expression between different…

Q: There are several instances which challenge the “one gene, one polypeptide” hypothesis. Describe TWO…

A: 1. Alternative splicing is a process that allows for the synthesis of numerous protein isoforms from…

Q: How does the HAEIII enzyme discriminate between the C-G polymorphism in the  TAS2R38  gene?

A: HaeIII catalyst cuts at the A GG:CC which is found at nucleotides 143-146 of the TAS2R38 gene.   The…

Q: a) Bioinformatics is an interdisciplinary field that integrates computer science with mathematics…

A: Genomic research is aided by using bioinformatics tools like BLAST (Basic Local Alignment Search…

Q: out transformation requires from 105 to 124 genes, collectively termed the com regulon. The com…

A: Transformation is a process in which the DNA is transformed or changed by taking up the DNA that is…

Q: Steven Frank and Laurence Hurst argued that a cytoplasmically inherited mutation in humans that has…

A: The inheritable disease that caused vision loss more in males and less in females is Leber…

Q: What sort of selection marker system will ensure that only E. coli transformed with pGLO will…

A: pGLO is a plasmid that is frequently used in genetic engineering experiments. It contains a number…

Q: Genetic linkage studies can usually locate the chromosomal position of a disease gene only roughly.…

A: The chromosomal theory of inheritance provides the idea that genes are located on the chromosomes.…

Q: Discuss the importance of linkage disequilibrium (LD) toassociation mapping of QTLs in humans.

A: The classical Mendelian traits are quantitative in nature which means, the traits which are easily…

Q: 3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the…

A: The pure breeding lines of mutant and wild type organism must be crossed to determine if the…

Q: Next-generation sequencing reveals that six new mutations have occurred in the coding regions of…

A: Next-generation sequencing is the second-generation high throughput method used to identify the…

Q: What are paralogous and orthologous genes? What are some of the explanations for the finding that…

A: Thus, a gene is a fundamental unit of inheritance, carrying coded information associated with a…

Q: A hypothetical gene for cephalosporin resistance is found to be carried by a transposon. Explain…

A: The three primary modes of antimicrobial resistance are (1) enzymatic breakdown of antibiotics, (2)…

Q: For each of the following scenarios describing gene annotation, choose the answer that best fits A…

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Q: How does bisulfite treatment coupled with PCR enable the identification of DNA methylation? And, How…

A: DNA methylation is an essential epigenetic process that plays a key role in various biological…

Q: . Figure 18-14 presents haplotype data for the G6PD genein a worldwide sample of people.a. Draw a…

A: A single nucleotide polymorphism, is a difference between individuals in a single spot in a DNA…

Q: Mutants of S. pyogenes Cas9 have been developed which recognize different PAM sequences, such as 5′…

A: A short DNA sequence, the protospacer adjacent motif (PAM), is often accustomed to mark correct…

Q: Genome annotation refers to ... 1.) lining up overlapping regions in short shotgun sequencing reads…

A: Introduction:- Genome consists of all the genetic and biological information of an individual…

Q: a) Let's say the two motif hits (CCACGAG and CCGCCAG respectively) turn out to be evolutionarily…

A: Motifs are mainly short, conserved sequence patterns that are associated with specific function of a…

Q: Include a description as to why disrupting the expression of each gene leads to the phenotype…

A: Caenorhabditis elegans (C. elegans) is a transparent, free-living roundworm that is a popular model…

Q: DNA markers have greatly enhanced the mapping of genes in humans. What are DNA markers, and what…

A: The chemical substance that is passed from the preceding generation to the succeeding generation is…

Q: . Let’s say that you have incredible skill and can isolate the white and red patches of tissue from…

A: Mutation It can occur due to errors in DNA copying during cell division, ionising radiation…

Q: A O 1 2 3 456 7 8 9 CG site number 1 2 3 4 5 6 7 8 9 CG site number *p<0.05 ##p<0.01 The viable…

A: The study discussed in the question examines the impact of BPA exposure on the methylation of the…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.