Recombination frequency between two linked loci is always less than 0.5 (or 50%). Why?

DNA fingerprinting does not study the whole chromosome. Explain.

he chances of an individual having a particular group of variable number tandem repeats (VNTRs) can be calculated. If 3 VNTRs are analyzed, one of which has 40 known variations while the other 2 have thirty known variations each, what is the chance of an individual having any specific banding pattern? a 36,000 b 100 c 1/100 d 1/36,000

If two genes are unlinked the recombination frequency will be?     25%     50%     75%     100%

The higher the recombination frequency (%), the more likely recombination will occur. The lower the frequency, the less likely recombination will occur. True or False

A pair of paralogous repeats, A and B, have 96% sequence similarity and therefore can promote non-allelic homologous recombination (NAHR). They exist in four possible arrangements in a genome, illustrated below as arrangements 1 – 4. What is the result of NAHR between repeats A and B in arrangement 1? A.Translocation between chromosomes 1 and 2 resulting in monocentric chromosomes B.Deletion or duplication of the region between A and B C.Translocation between chromosomes 1 and 2 resulting in acentric and dicentric chromosomes D.Inversion of the region between A and B

A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19 belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7 belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the disease. By using a very stringent threshold, which of the following conclusions is correct? O A.Z is approximately 4.03, indicating a linkage O B. Z=0.25, indicating no linkage OCZ=0.2, indicating no linkage O D.Z is approximately 4.19, indicating a linkage

Genes A and B are 7.5 map units apart on one chromosome. Genes C and D are 8.0 map units apart on a second non-homologous chromosome. • The recombination frequency between A and B is? • The recombination frequency between A and C is? • The recombination frequency between C and D is? • The recombination frequency between B and D is?