Question: Let's say that you are able to colonize the gastrointestinal tract of mice with predominantly firmicutes microflora. There would likely be. a. weight gain in the mice b. less absorption of short-chain fatty acids by the mice c. increased inflammation in the mice D: two of the above are correct E: a, b, and c are all correct
Question: Let's say that you are able to colonize the gastrointestinal tract of mice with predominantly firmicutes microflora. There would likely be. a. weight gain in the mice b. less absorption of short-chain fatty acids by the mice c. increased inflammation in the mice D: two of the above are correct E: a, b, and c are all correct
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Let's say that you are able to colonize the gastrointestinal tract of mice with predominantly firmicutes microflora. There would likely be.
a. weight gain in the mice
b. less absorption of short-chain fatty acids by the mice
c. increased inflammation in the mice
D: two of the above are correct
E: a, b, and c are all correct
Transcribed Image Text:lean
obese
1 bacteriodetes
1 firmicutes
weight loss reverses this i.e. more bacteriodetes;
less firmicutes
- promotes breakdown and
absorption of fatty acids and
polysaccharides
colonize with microflora from
lean OR obese (ob/ob) mice
OUTCOME:
- colonization with ob/ob
microflora leads to
increased body fat in
only 2 weeks !
Germ-free mouse
- no gut microflora
- protected against obesity
10
Turnbaugh et al. Nature Vol 444: 1027, 2006
Transcribed Image Text:HOW Does the Gut Microflora Contribute to Obesity ???
"Obese" bacteria are thought to"
1. have greater short chain fatty acid production, which can act an an
extra energy source for the host
2. increase gut permeability, leading to increased absorption of
lipopolysaccharides (LPS) which cause inflammation and metabolic
disorders
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