Place the steps below in the correct order to accurately reflect the steps by which a secretory protein is co-translationally imported into the lumen of the endoplasmic reticulum:As the polypeptide elongates and translocates into the ER, the signal peptidase cleaves the signal peptide.The SRP binds the SRP receptor, directing the ribosome to dock on the ER membrane.Termination of translation, results in the release of the polypeptide into the ER lumen,release of the ribosome from the ER membrane, and closing of the channel.The signal recognition particle (SRP) binds to the signal sequence on a newly synthesized polypeptide and stalls translation.The channel in the ER membrane opens and the polypeptide is inserted into the ER lumen.The SRP is released.A.6-4-2-3-1-5B.4-2-5-1-3-6C.3-1-6-2-4-5D.1-2-3-4-5-6E.2-6-1-5-4-3

Protein synthesized by membrane bound ribosome translocate the ER (endoplasmic reticulum) membrane…

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Place the steps below in the correct order to accurately reflect the steps by which a secretory protein is co-translationally imported into the lumen of the endoplasmic reticulum:

As the polypeptide elongates and translocates into the ER, the signal peptidase cleaves the signal peptide.
The SRP binds the SRP receptor, directing the ribosome to dock on the ER membrane.
Termination of translation, results in the release of the polypeptide into the ER lumen,

release of the ribosome from the ER membrane, and closing of the channel.
The signal recognition particle (SRP) binds to the signal sequence on a newly synthesized polypeptide and stalls translation.
The channel in the ER membrane opens and the polypeptide is inserted into the ER lumen.
The SRP is released.

A.6-4-2-3-1-5

B.4-2-5-1-3-6

C.3-1-6-2-4-5

D.1-2-3-4-5-6

E.2-6-1-5-4-3

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