Oxidation of DNA bases is mutagenic. An oxidized form of guanine,8-oxoguanine, can base-pair with adenine, leading to errors in DNAreplication. A gene called mutT acts to minimize the tendency of A-oxoGbase pairs to form. The mutT gene product was purified and shown to be anenzyme. Speculate on the reaction catalyzed by this enzyme.

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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Oxidation of DNA bases is mutagenic. An oxidized form of guanine,
8-oxoguanine, can base-pair with adenine, leading to errors in DNA
replication.
A gene called mutT acts to minimize the tendency of A-oxoG
base pairs to form. The mutT gene product was purified and shown to be an
enzyme. Speculate on the reaction catalyzed by this enzyme.

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