mutations to cause distinct symptoms? (two to three sentences) (Think about why various mutations in different genes cause different illnesses.) 2. What can family history teach you about a patient's muscular dystrophy inheritance and, hence, genetic basis? (two to three sentences) 3. The X-chromosome contains the mutation that causes Duchenne Muscular Dystrophy (DMD). Explains how this impacts DMD inheritance and why DMD patients are disproportionately male. (two to three sentences)

Please help, doesn't it usually start before the promoter or after, please just give me a brief explanation

I Review Lesch-Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self- mutilation. Part A What is the probability that the first son of a woman whose brother has Lesch-Nyhan syndrome will be affected? Express your answer as a fraction (example 1/16). Submit Request Answer Part B If the first son of the woman described in (a) is affected, what is the probability that her second son is affected? Express your answer as a fraction (example 1/16). Submit Request Answer

Can We Talk About Sex?   Abstract: A three–year–old female undergoes elective inguinal hernia repair and unexpectedly is found to have testes in the hernia sacs. A recommendation is made not to disclose the patient’s genotype to her mother. This case study addresses the ethical conflict of whether to disclose the patient’s male genotype to the parent that has been raising the child as female.   This case highlights the ethical risks and potential consequences later in life of not disclosing a patient’s CAIS diagnosis and treatment. Conversely, what would the consequences be for disclosing?

Genetic disorders Complete the following statements to describe several genetic disorders and their symptoms. Choices can be used more than once. The disorder called causes blue-colored skin, sickle-cell disease osteogenesis imperfecta The disorder called that leads to weakened, brittle bones. causes defective collagen methemoglobinemia autosomal dominant The disorder called causes abnormally thick mucus in the bronchial tubes and pancreatic ducts. autosomal recessive The disorder called leads to progressive cystic fibrosis degeneration of neurons in the brain. alkaptonuria The disorder called causes urine to be black. Huntington disease acer %23 24 & 4 8. 9. e y u < 6

12. A. B. C. D. 9:24 A. .5G prairiestate.desire2learn.com does that prove ne is the father of the baby or the person who committed the crime? Explain your answer. Hemophilia is an x-linked disease in which the blood does not clot normally; it is sometimes called "bleeder's disease." Hemophilia is caused by a recessive allele (h). The dominant allele (H) produces blood that clots normally. What is genotype of a man who is a hemophiliac? What is the genotype of a man with normal blood clotting? What is the genotype of a woman with normal clotting blood if her father was a hemophiliac? If a man with normal clotting blood and a heterozygous woman have children together, what would you expect for the genotypes and phenotypes of the children? 13. A dominant x-linked allele (B) gives normal color vision but the recessive allele (b) causes red-green color blindness. What is the genotype of a man with normal color vision whose father was color- blind?

See photo attached.

Discuss at least three of the disorders of focusing. What is the complete epigenetic origin which should include the genetic/biological origin and the environment influence related to these disorders of focusing.

Jonah and Jana are siblings. Jonah has the genetic disorder cystic fibrosis, caused by inheriting one copy from each parent of a mutation in the CF gene. Jana does not have cystic fibrosis. Which of the following statements is/are true? (Select all that are true)   a)Jana does not have the gene that when mutant causes cystic fibrosis. b)Jana has the gene that when mutant causes cystic fibrosis. c)Jana has two copies of the allele that causes cystic fibrosis. d)Jana does not have two copies of the allele that causes cystic fibrosis.

4). p53 (sometimes called TP53 for “tumor protein 53") is a human tumor suppressor gene that is mutated in the majority of human cancers (many tumor types). a. For each of the mutations described below (i-iv): is this a mutation you would expect to find when sequencing p53 alleles from tumor cells? Why or why not? i. A missense mutation encoding a hyperactive form of the protein. ii. A deletion of the gene. iii. An insertion in the promoter that increases transcription 10-fold. iv. A nonsense mutation. b. When sequencing the p53 gene in tumor cells, would you expect to find only mutant version(s) of the gene or a mix of mutant and wild type versions? c. For any of the mutations you said you would expect to find in tumor cells, would you expect tumor cells to be homozygous (same mutation on both chromosomes)? Why or why not? d. Individuals with Li-Fraumeni syndrome have a very high risk of tumors originating in various tissues due to inheritance of a loss-of-function mutant allele of…