- Multiple choice Allopurinol is an inhibitor of xanthine oxidase. Administration of allopurinol to a patient with gout and normal HG-PRT levels would be expected to lead to all of the following EXCEPT: A. decreased de novo synthesis of IMP B. increased xanthine in the blood C. increased levels of PRPP D. decreased urate in the urine 2. Which of the following unique attributes creates a steroid? A. 1 carboxyl group B. 4-fused carbon rings C. 2-fused oxygen molecules D. 3-fused hydrogen chains
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- BIOMOLECULES Please answer the questions properly. - Multiple choice Qyestion 1: If a cell has an adequate supply of adenine nucleotides but requires more guanine nucleotides for protein synthesis: 1. Glutamine-PRPP amidotransferase will not be fully inhibited. 2. AMP will be a feedback inhibitor of the condensation of IMP with aspartate. 3. ATP will stimulate the production of GMP from IMP. 4. ATP will inhibit nucleoside diphosphate reductase. А. 1, 2, and 3 В. 2 and 4 С. 1, 2, 3, and 4 D. 1 and 3- MULTIPLE CHOICE - Please answer properly QUESTION : In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. decrease de novo purine synthesis C. decrease urate synthesis D. increase PRPP levels (Phosphoribosyl pyrophosphate)BIOMOLECULES - Please answer the questions properly. - Multiple choice Qyestion 1 : If a cell has an adequate supply of adenine nucleotides but requires more guanine nucleotides for protein synthesis: 1. Glutamine-PRPP amidotransferase will not be fully inhibited. 2. AMP will be a feedback inhibitor of the condensation of IMP with aspartate. 3. ATP will stimulate the production of GMP from IMP. 4. ATP will inhibit nucleoside diphosphate reductase. A. 1, 2, and 3 B. 2 and 4 C. 1, 2, 3, and 4 D. 1 and 3
- ACTIVITY4; ETC Crossword Puzzle Direction Answer the questions or complete the statements below to fill in the puzzle Across Down 3. Complex lis also known as the 1. Heptachior has been hinked to health issue complex 4. In stage of the ETC, the heptachlor is 2. is when the body has elevated levels inhibited of calcium 6. Complex Il is linked directly to the 5. Rotenone is most commonly found in cycle 8. Complex is inhibited in this pesticide, 7. Rotenone is most abundant in the part of the plant 9. There are (number) complexes in the 10. Heptachlor is commonly spread in ETC form 13. There are (number) ATP produced 11. Complex is also known as the per glucose molecule from the electron Succinate Dehydrogenase Complex transport chain 12. Heptachlor is a man-made substance. 14.type of reaction is used to transfer electrons from electron donors to electron acceptors 15. compound receives electrons from NADH 16. (plant) is where the rotenone comes from 17. in a eukaryotic cell, most of the…Y ANTIBODIES DIETARY B12 PERNICIOUS ANAEMIA HYDROXYCOBALAMIN 5. Pernicious anemia is a disease in which the intestine is unable to absorb vitamin B12, frequently due to the loss of the generically named "intrinsic factor" produced by the parietal cells of the stomach lining. Intrinsic factor is a glycoprotein that binds to vitamin B₁2 and is required for its uptake in the ilium. Vitamin B12 is synthesized only by microbes, and we get it either from digesting animal protein or from our commensal microbiome. Vitamin B₁ is unique among metabolic cofactors in that it contains the trace element cobalt, coordinated in a corrin ring structure that is similar to the porphyrin ring system in heme. Loss of intrinsic factor, often through autoimmunity, results in the inability to absorb B12 and ultimately a loss of red blood cells that results in anemia and can be deadly ("pernicious"). ILEUM NUMBNESS (a) In pernicious anemia, N 5-methyltetrahydrofolate accumulates, and cells run out of…BIOMOLECULES - Please answer the questions properly. - Multiple choice 1. Major controls of de novo AMP synthesis include: 1. allosteric inhibition by GMP. 2. allosteric inhibition by AMP. 3. availability of PRPP. 4. stimulation by GTP A. 1, 2, and 3 B. 1, 2, 3, and 4 C. 2 and 4 D. 1 and 3
- BIOMOLECULES - Please answer the questions properly. - Multiple choice 1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesisBIOMOLECULES - Please answer the questions properly. - Multiple choice 1. What is the reason why the transition state of a catalyzed reaction is lower has lower energy compared to an uncatalyzed reaction? A. because enzymes only work at low temperatures B. because of favorable interactions with the substrate C. because of enthalpic interactions between the enzyme and the transition state D. A and B 2. The antibody-antigen binding site is different from an active site of an enzyme because an enzyme’s active site* A. is complementary to a specific ligand B. catalyzes a chemical reaction C. contains amino acids without sidechains D. contains modified amino acidsin human 2. Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. For the treatment of hyperuricemia and gout. several medications are used to inhibit the activity of xanthine oxidase and reduce the production of uric acid. You are a biochemist and just discovered a chemical that can inhibit the activity of the human xanthine oxidase. When analyzing its mode of inhibition, you found that the enzyme inhibitor complex requires 450 kJ.mol to dissociate and that it displays kinetics somehow similar to noncompetitive inhibition. You sent your inhibitor to the ministry of health for approval as a medication for gout. Based on the data provided, are they going to authorize it as a medication or not? Explain?
- Hi, please help me with my assignment. All questions please. 1. The metabolic precursor for the production of most eicosanoids isa. Cholesterolb. Sphingosinec. Arachidonic acidd. Eicosapentanoic acids2. Aspirin reduces inflammation and fever by inhibiting the formation of which of thefollowing types of messenger lipids?a. Prostaglandinsb. Thromboxanesc. Leukotrienesd. Progestins3. Which of the following is a correct pairing of concepts?a. Male sex hormones: androgensb. Pregnancy hormones: estrogenc. Female sex hormones: progestinsd. After menopause hormones: estradiol4. Which of the following substances is associated with Na+/K+ balance in the human body?a. Cortisolb. Cortisonec. Aldosteroned. Prednisolone5. Which of the following statements concerning steroid hormones is correct?a. Some, but not all of them, are cholesterol derivatives.b. Some, but not all of them, are glucose derivatives.c. Some, but not all of them, are fatty acid derivatives.d. All of them are cholesterol…me (1).docx BIU A A- are they different? 3. What are three ways that 2-deoxystreptamine (2-DOS) aminoglycosides can inhibit protein synthesis? 4. Chloramphenicol: a. Where does this drug bind? b. How does it inhibit protein synthesis?BIOMOLECULES - Please answer the questions properly. - Multiple choice 1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesis