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1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesis

1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesis

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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BIOMOLECULES - Please answer the questions properly. - Multiple choice 1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesis
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