1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesis

1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesis

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter31: Completing The Protein Life Cycle: Folding, Processing, And Degradation

Section: Chapter Questions

Problem 15P

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