16. Which of the following statements is true for the shown reaction?C²-S-CoA CH₂-C-S-COA çoo-CH₂CH ₂H₂C-C-OHCH₂COOSA. The reaction occurs in the muscleB. The reaction occurs during B-oxidationC. To be transported through the blood stream, P needs to associate with albumenD. P can be easily converted to glucoseE. All of the aboveF. None of the above17. The shown reaction is one of the four repeating steps during fatty acid ß-oxidation. Which of thefollowing statements is correct for the shown reaction?HC=OCH3PHO HAs-CoABI+CH₂-8-5-C²-S-COAA. The small molecule in box A is FADB. It is the second oxidation reaction during B-oxidationC. Both A and BD. Neither A nor B

Acetyl CoA produced from fatty acid oxidation in the hepatic cells has two possible fates:enter TCA…

Answered: 16. Which of the following statements…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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2. The mechanism of HMG-CoA reducatse enzyme activity involves several stages. For the catalytic reaction to proceed, another substrate known as NADPH, which acts as a reducing agent is required. The kinetics of enzyme activity with NADPH at non-limiting amounts of HMG-CoA in the absence or presence of compactin is shown below. a) Based on the description above, which of the six types of enzymes does HMG-CoA reductase belong to? b) What is the Km for the reaction with no inhibitor present? Do NOT forget the units. Answers can be expressed either as a fraction or in decimals. c) What happens the measured Km with increasing amounts of compactin? (select one) increases decreases does not change d) What happens to the measured Vmax with increasing amounts of compactin? (select one) increases decreases does not change e) Based on your answers above, what type of inhibitor is compactin relative to its effects on enzyme activity NADPH? with -60 -40 1/V, (nanomoles/min)-1 -20 0.2 0.18 0.16…
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3. Palmitate is radiolabeled at the ¹¹ position using ¹4C. This is added to a liver homogenate. Trace the flow of the radiolabeled carbon as the palmitate is catabolized and then used for ketone body production. If a molecule can have the radiolabel in two different positions, make sure to show both possibilities. Present your work as a progression through the catabolic pathway, showing the product(s) from every round of B-oxidation and the subsequent steps to ketone body production that contain the radiolabel. Make sure each step also shows any needed cofactors and/or enzymes.
The pentose phosphate shunt is likely to be active when: a AMP levels are high b the organism has not had a meal for a long time. c an organism is growing d fatty acid beta-oxidation is active.
The reaction below catalyzed by phosphoglycerate mutase is, 3-phosphoglycerate 2-phosphoglycerate an isomerization. A. В. a group transfer reaction. a reversed aldol condenstion. C. Op an oxidation reduction reaction. E. Cand D
6. Lovastatin (see picture), is a potent competitive inhibitor of HMG-COA reductase (B-hydroxy- B-methylglutaryl-COA reductase). In addition, the synthetic compound, Terbinafine (see picture), is a potent inhibitor of squalene monooxygenase. Both compounds could be used to treat hypercholesterolemia, a genetic disorder where the patient synthesizes too much cholesterol regardless of dietary intake of cholesterol. a. Predict and explain the effect of these drug on serum cholesterol levels in humans. b. Based on squalene monooxygenase's role in synthesizing sterols, explain why terbinafine is marketed as an anti-fungal agent, and not for hypercholesterolemia.
3. Below are the fates of the carbon skeletons of amino acids. Fill out the table with the corresponding amino acid source of each metabolic intermediate Pyruvate (list at least 5) Аcctyl CoA Alpha-ketoglutarate 1. 1. 1. 2. 2. 2. 3. 3. 3. 4. 4. 5. 5.
21. How many carbons are removed from fatty acyl CoA in one turn of B-oxidation spiral? E. 6 22. B-oxidation of fatty acids is promoted by which of the followings? D. Acetyl CoA A. 1 С. З D. 4 B. 2 A. ATP B. NAD+ C. FADH2 E. Propionyl CoA
14. Which of the following statements is true for the shown reaction? P-O-CH₂ HOO-P ក្រុង D P-O-CH₂ OH MOTHE OH ночно HO OH B A A. Stimulation of the reaction slows down glycolysis B. The reaction is the rate-limiting step of gluconeogenesis C. Both A and B D. Neither A nor B

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