Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Many viruses that infect eukaryotic cells express genes that alter
the regulation of host gene expression to promote viral replication.
For example, herpes simplex virus-1 (HSV-1) expresses a
protein called ICP0, which is necessary for successful viral infection
and replication within the host. Lutz et al. (2017. Viruses
9: 210) showed that ICP0 can act as a ubiquitin ligase and target
the redundant transcriptional repressors ZEB1 and ZEB2,
which leads to upregulation of the miR-183 cluster (a set of three
miRNAs transcribed from the same locus).

Speculate on how miR-183 cluster upregulation may benefit
the virus.

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