Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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The following pedigree illustrates the inheritance of ringed hair, a
condition in which each hair is differentiated into light and dark zones.
What mode or modes of inheritance are possible for the ringed-hair trait
in this family?
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- Type 1 albinism in humans is a rare hereditary condition associated with a reduced amount of active tyrosinase, an enzyme required for the conversion of the amino acid tyrosine to the dark pigment melanin. In the pedigree above, males are indicated by squares, females by circles and individuals with type 1 albinism are indicated by shading. Use A and a for the dominant (sufficient active tyrosinase) and recessive alleles (absent or insufficient tyrosinase activity), respectively. Remember that, when genotype is not known for a dominant phenotype, an m-dash is used (A- = AA or Aa). Match the genotypes of the indicated family members as specifically as possible based on the pedigree data. Except where necessary to explain the pedigree, assume that the individuals marrying into the family are homozygous wild-type. v Individual A - v Individual B 1. A- v Individual C 2. Aa Individual C v Individual Earrow_forwardCystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f What is the genotype of individual #13? A) ff B) FF C) Ff D) it is impossible to tellarrow_forwardIn certain species of horses, a roan coat color (mixed red and white hairs) occurs in the heterozygous (Rr) offspring of red (RR) and white (rr) homozygotes. Which type type of inheritance does this example represent?arrow_forward
- Although in reality the inheritance of cleft chin (e.g., the deep chin dimple seen in Ben Ameck) is slightly more complicated, for now let's assume that the presence or absence of a cleft chin is determined by one gene. By studying pedigrees, we know that no child possesses a cleft chin unless at least one parent does (either the mom or the dad). Hint: Based on that last statement, you should now know the mode of inheritance! What is it? (Remember Recessive traits can hide, but dominant traits never do! ) O Cleft chin is a dominant trait. O Cleft chin is a recessive trait.arrow_forwardThis pedigree (below) shows inheritance of a genetic disorder in a family. Assume the trait is rare. What is the mode of inheritance for this trait? [Select] You know this because that mode of inheritance is characterized by: [ Select] • An affected male parent passes the allele to [Select] and [Select] individuals who have the allele express it and and [Select] of his daughters. • An affected female parent passes the allele to [Select] of her daughters. ㅇㅁㅇㅁ î то ◆ of his sons of her so ?arrow_forwardthe pedigree below shows the inheritance of a newly identified eye color gene. Assume 100% penetrance and expressivity. Use the pedigree to find: 1. Identify the mode of inheritance (either autosomal dominant, or autosomal recessive) 2. Argue why your mode of inheritance must be correct. Your argument should cite specific individuals from the pedigree. (For example, the top left individual is person I-1).arrow_forward
- Duchenne muscular dystrophy is an inheritable disorder that results in muscle weakness, leading to walking and breathing difficulties and heart disease. Which of the following is a valid conclusion about the Duchenne muscular dystrophy pedigree shown above? Select one: a. Only individuals I-2 and II-4 are confirmed carriers of the Duchenne muscular dystrophy allele. b. Individual II-3 can only pass on the Duchenne muscular dystrophy allele to individuals III-2 and III-4. c. Without further evidence, the genotypes of individuals II-2 and III-2 cannot be determined. d. Only individuals I-1 and II-3 are confirmed carriers of the Duchenne muscular dystrophy allele.arrow_forwardAn unaffected woman for a human disorder marries and unaffected man and they have children. This results in 3 affected sons, and one unaffected daughter, which ends up having children later on with an unaffected man and has 2 affected sons. A) Draw a simple pedigree diagram for this family, including a legend. B) What is the likely mode of inheritance of this trait: Please explain C) Provide the genotypes of the original mother and the daughter. Use a capital letter for the dominant allele and lowercase letter for the recessive allele. D) If one of the affected sons from the original marriage marries a 2nd cousin that is a carrier of this trait and has children, what is the probability that they will have 3 affected sons?arrow_forwardDuchenne muscular dystrophy is an inheritable disorder that results in muscle weakness, leading to walking and breathing difficulties and heart disease. Which of the following is a valid conclusion about the Duchenne muscular dystrophy pedigree shown above? Select one: a. Only individuals I-2 and II-4 are confirmed carriers of the Duchenne muscular dystrophy allele. b. Individual II-3 can only pass on the Duchenne muscular dystrophy allele to individuals III-2 and III-4. c. Without further evidence, the genotypes of individuals II-2 and III-2 cannot be determined. d. Only individuals I-1 and II-3 are confirmed carriers of the Duchenne muscular dystrophy allele.arrow_forward
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