Higher rates of mutation are found in RNA viruses. Why? Replication of their genomes does not involve proofreading. RNA viruses can incorporate a variety of nonstandard bases. RNA nucleotides are more unstable than DNA nucleotides. RNA viruses are more sensitive to mutagens.
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- Which viruses have potential for the highest mutation rates, DNA or RNA viruses? Explain O DNA viruses as DNA polymerases do not proofread thus make many mistakes/mutations when viral RNA is copied DNA viruses as DNA polymerases do not proofread thus make many mistakes/mutations when viral DNA is copied RNA viruses as DNA polymerases do not proofread thus make many mistakes/mutations when viral DNA is copied RNA viruses as RNA polymerases do not proofread thus make many mistakes/mutations when viral RNA is copied and DNA polymerases do proof readA" is a retrovirus. It can integrate DNA into random sites of human genome. Another virus "B" can integrate DNA at a specific site of human genome. Which one of these viruses would make a better vector for gene therapy? Briefly explain.Which of the following mutagens can substitute bases in DNA because of structural similarity? Group of answer choices nitrous acid aflatoxin base analogue intercalating agent
- Remdesivir is an antiviral drug used to treat SARS-CoV-2 infections. It is a broad-spectrum antiviral, meaning it has activity against many different viruses. Remdesivir can be incorporated into a new RNA chain as a virus replicates and can interfere with the viral replication machinery. Template RNA Elongation New RNA SARS-CoV-2 RNA polymerase Template groove Nucleotide entrance Nucleotides Remdesivir Figure 1. A representation of remdesivir and the viral replication machinery for SARS-CoV-2. 6. Figure 1 shows that remdesivir "mimics” an important component of RNA replication. Which specific component of RNA replication has a structure like that of remdesivir? 7. Propose a hypothesis about how remdesivir might inhibit the virus's replication process.How are poly-adenosine tails added to subgenomic mRNAs of RNA viruses? Repeated uracil bases on the template cause the polymerase to slip backwards and recopy the sequence Polymerases copy a 200 base string of uracils found in some RNA viral genomes Polymerases copy a 200 base string of uracils added to the template during circularization Viral mRNAs undergo post-translational modifications, which include splicing of introns, a 5'-cap, and a 3'-poly-A tailA frameshift mutation is caused by a: a. nucleotide substitution b. three-base insertion c. premature stop codon d. one-base insertion e. two-base deletion
- Many virologists note that viruses which have a genome made up of RNA will tend to evolve faster than those viruses whose genome is made up of double-stranded DNA. Most evolutionary biologists now accept that RNA was the first nucleic acid molecule to evolve to store information. Why is this early “RNA world” more likely when you consider how RNA polymerases (such as primase) and DNA polymerases start replicating nucleotide chains?The following is an example of what type of mutation? Normal DNA: 5' - ATGACGTCA - 3' Mutated DNA: 5' - ATGAGTCA - 3' Deletion Insertion Frameshift SilentViruses with negative sense RNA genomes typically, make proteins by: (Ignore retroviruses, and the unusual characteristics of coronaviruses) Translation of short RNA transcripts generated by RDRP Generating a DNA copy, which is then transcribed by host RNA polymerase. Translation of the viral genome by host ribosomes. Production of a polyprotein, which must be cleaved into smaller proteins. Generating a negative sense genome copy, which is then translated by host ribosomes.
- Bacteria exposed to viruses incorporate sections of the virus’s DNA into the CRISPR array sequences in their genome. This mechanism allows bacteria to fight off the viruses, like an immune response: the information in CRISPR spacers served as “coordinates” for recognizing and cutting up invading DNA sequences. Describe what might happen under the conditions described after a bacteriophage infects a bacterial cell and releases its DNA into the bacterial cell. Explain why: The cas genes on the bacterial genome contains a frameshift deletion mutation that alters the function of the protein The bacteria will be unable to elicit an immune response and will succumb to the phase infectionWhich of the following viral nucleic acids can be used as a template to produce mRNA? Select all that apply. plus strand DNA plus strand RNA minus strand RNA minus strand DNABacteria exposed to viruses incorporate sections of the virus’s DNA into the CRISPR array sequences in their genome. This mechanism allows bacteria to fight off the viruses, like an immune response: the information in CRISPR spacers served as “coordinates” for recognizing and cutting up invading DNA sequences. Describe what might happen under the conditions described after a bacteriophage infects a bacterial cell and releases its DNA into the bacterial cell. Explain why: 1. The invading phage DNA is recognized by the Cas proteins but not inserted into the CRISPR array region of the bacterial genome: The bacteria will be unable to elicit an immune response and will succumb to the phase infection 2. The cas genes on the bacterial genome contains a missense mutation that increases its cleavage/cut activityThe bacteria will elicit an immune response that will successfully fight the phage infection