How would you explain gene expression? How is it that a particular genotype is actually expressed as a phenotype? I am looking for details here, including an explanation of the molecular mechanisms involved.
Q: Using coat color in mice and the development of female honeybees as examples, explain how dietary…
A: The inheritance of phenotypic characteristics without any changes at the genetic level is called…
Q: What are the differences and similarities among the three classes of monoallelic gene expression?
A: The phenomenon of the expression of one allele of a gene is called monoallelic expression. The…
Q: You are curious to identify the region of the gene X sequence that serves as an enhancer for gene…
A: Nascent RNA (ribonucleic acid) sequencing analysis is a tool for enhancer identification. Some…
Q: In a first attempt to describe the relationship between genes and phenotypes, Beadle and Tatum in…
A: One gene-one enzyme hypothesis was discovered in the early 1940s that each gene controls the…
Q: Which of the following is TRUE about eukaryotic gene expression?
A: Eukaryotic Gene Expression is one of the most complex processes because every cell in the body had…
Q: You found a strain of mutant fruit flies (Drosophila) living on the rotten bananas in your dorm…
A: Maternal effect genes are influencing the development of an embryo when transferred in the form of…
Q: Discuss the similarities and differences of phenotypic variations that are caused by epigenetic gene…
A: Genetics is a branch of science that deals in the study of genes, heredity, and genetic variation of…
Q: What is Differences Between Prokaryotes and Eukaryotes in the Details of Gene Expression?
A: Gene expression means genes express its function like DNA carry information can be express as…
Q: Suppose you had funding to do a genome-wide gene expression experiment (20,000 genes). You can use…
A: Gene expression analysis involves determining if a specific gene is being expressed under specific…
Q: Why are diseases due to microsatellite amplification, even though they have a monogenic pattern of…
A: The classical inheritance is the type of inheritance pattern in which mendelian laws are followed…
Q: Beadle and Tatum’s BEST contribution to how gene expression is understood can be summarized as what?…
A: Beadle and Tatum were able to confirm Garrod's hypothesis with the help of genetic and biochemical…
Q: Briefly explain how gene expression occurs at the molecular level.
A: Genes are the basic biological unit of heredity. They are a segment of deoxyribonucleic acid (DNA)…
Q: The complex set of chemical markers and genetic switches that regulate gene function is called the
A: The regulatory network components of the genes are called genetic switches. They help to switch on…
Q: What is effect of turning on and off of genes? How do we measure gene expression? What is gene…
A: Answer1) The effect of turning a gene on and off is observed on its expression and ultimately on the…
Q: n and Give examples of mutations that can have global effects on gene expression.
A: Mutation is defined as any change or alternation in the sequences of DNA or, in the case of…
Q: What are the basic differences between prokaryotic and eukaryotic regulation of gene expression?
A: Introduction - A single prokaryotic cell makes up a prokaryote. In plants, animals, fungi, and…
Q: Many genes generate different products depending on the type of cell expressing the gene. How is…
A: The process of generation of different protein products from the same pre-mRNA transcript is called…
Q: Epigenetic markers tell your genes to switch on or off. What are two environmental factors that can…
A: While most environmental exposures affect somatic cells and do not allow for transgenerational…
Q: Given a mutation in the promoter, coding region, and/or non-coding region of a gene, explain how…
A: The mutation is a sudden heritable change in the genetic makeup of a cell which mostly results in…
Q: Phenotypes can be controlled by many processes besides the actual genotype present. Explain one…
A: Epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA…
Q: You’re reviewing a manuscript in which the researcher claims that Gene A is more highly expressed…
A: FPKM denotes the fragments per kilobase million. It is used in RNA sequencing to have two reads…
Q: Which of the following is an explanation for how there can be differential gene expression…
A: Ans-C) There are unique combinations of transcription factors in different tissues of the organism…
Q: Why is it useful to survey expression of the entire genomeunder particular conditions?
A: Expression of the entire genome involves studying expression and the variation in expression in a…
Q: how the regulation of DNA expression by the proteins that are bound to it and their inheritance…
A:
Q: Proteins A,B,C, and D in the diagram are encoded by different genes and interact with each other.…
A: Answer. There are many different types of mutations that can occur in a coding sequence that can…
Q: What are epigenetic modifications? a. the addition of reversible changes to histone proteins and DNA…
A: Epigenetic mutation can be defined as abnormal methylation level that can result in aberrant gene…
Q: Discuss factors that might influence the activity of DNA-binding proteins (transcription factors)…
A: Transcription is that the process where a gene's DNA sequence is copied (transcribed) into an RNA…
Q: How do we know that small noncoding RNA molecules canregulate gene expression?
A: A non-coding RNA is a kind of RNA molecule that is not translated into a protein. The DNA sequence…
Q: Which of the following statament is NOT TRUE about gene expression?
A: Central dogma consists of replication, transcription and translation.Replication is the process of…
Q: Which of the following specific examples of gene expression control is incorrectly matched?
A: Answer: GENE EXPRESSION = It is a process by which an information from a gene is used to synthesize…
Q: List and describe four mechanisms used during eukaryotic regulation of gene expression that are NOT…
A: Eukaryotes means those organisms which has true nucleus(true nuclear envelope)while prokaryotes have…
Q: Please study the diagram above on eukaryotic gene expression. In order to provide instructions for…
A: EXPLANATION : Noncoding DNA is also found within most of the eukaryotic genes. Such genes have a…
Q: What steps are necessary and unnecessary for non-protein coding genes?
A: The translation is the process of analyzing the mRNA message in order to produce a protein. It is…
Q: Your friend has discovered that the same human promoter is responsible for producing two different…
A: We have a biomolecule , that is our dna which have all the genetic information. It Ultimately makes…
Q: At the molecular level, how do you think a gain-of-function mutation in a developmental gene might…
A: Mutations are referred to as the sudden heritable changes in the deoxyribonucleic aid of an…
Q: What are the Effects of One Gene on the Expression of Another Can Reveal the Order of Action?
A: When the effect of gene is modified under the influence of another gene, that is is known as…
Q: What are the two major processes that allow a gene to be expressed? What is the difference between…
A: Gene expression. Process in which encoding of genetic material take place which contain information…
Q: How can this identical set of genetic instructions produce different types of cells?
A: Genes are hereditary components that are located on the chromosomes. They can be passed on from one…
Q: Discuss in your own wordings the concept of gene expression. proper explanation and diagram
A: The genetic material present in the nucleus stores the genetic information that is expressed in the…
Q: Give two examples of how gene expression may be repressed without altering the coding sequence.
A: Epigenetics is the study of how our behaviors and environment affect the way our genes work.
Q: Describe two different types of pre-transcriptional control of gene expression? Give an example of…
A: Gene expression can be controlled at various levels which include Pre transcription regulation…
Q: Why are some genes expressed and some not?
A: Gene expression is dependent on many factors Genotype of the individual Environmental Status Gene…
Q: Do the same mechanisms that govern gene expression operate in bacterial cells and eukaryotic cells?…
A: The central dogma of molecular biology was given by Crick to explain the flow of genetic information…
Q: Explain why many traits encoded by mtDNA and cpDNA exhibit considerable variation in their…
A: The genetic material of a cell is found in both the nucleus and the cytoplasm. The characteristic…
Q: Why is it that every cell needs to contain the DNA for the entire body when only a few of its genes…
A: Every cell contains the DNA for the entire body but a few are expressed by its cell type. The…
Q: What parts of the genome are reversibly methylated? How does this affect gene expression?
A: DNA methylation is a biological mechanism in which methyl groups are introduced to the DNA molecule.…
Q: Describe four differences between prokaryotic and eukaryotic gene expression.
A: Genetic is the branch of science that deals with genetic material like genome, genes, DNA, and…
Q: Why are some genes expressed and some not? Please be as detailed as possible.
A: Genes are a set of nucleotides sequence that carries information to be passed on from one generation…
Q: Are all of your genes expressed in every cell in your body? Explain your answer and include an…
A: Ans. We have trillions of cells in our bodies. A variety of different organelles, such as…
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- this is what i have said about this image so far, what else can be said aswell including the raw count column. " Interpreting the results of an RNA-Seq analysis is pivotal in understanding the underlying genetic mechanisms of diseases such as breast cancer. In this analysis, Figure 1 provides comprehensive data on differentially expressed genes associated with breast cancer. By delving into the provided information, we can gain valuable insights into the molecular landscape of this disease. First focus is on the gene with the highest fold change, EYA4, situated on chromosome 6. With a staggering fold change of 3604.4176, EYA4 exhibits an unprecedented level of overexpression in cancerous cells compared to normal cells. This profound alteration suggests a pivotal role for EYA4 in breast cancer pathogenesis. The log2 fold change of 11.81555 further emphasizes the magnitude of this difference in gene expression. Statistical significance is evident, with an exceptionally low p-value of…1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Please EXCLUDE the use of CRISPR from consideration. A. Will you use germline or somatic cell gene therapy? Please NAME and DEFINE the form of gene therapy selected, then explain WHY this is the most appropriate choice.1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Other scientists have suggested that it might be possible to use CRISPR to treat this genetic disorder in affected individuals. (i) First, what is CRISPR? (BRIEFLY describe what it is and how it works). (ii) Briefly describe how CRISPR could be utilized in treating genetic conditions such as Batten disease.
- 1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). a) Hypothetically, what specific type of VECTOR will you use to perform your gene therapy? Please select from the following list of potential vectors: disabled retrovirus, adenovirus, adeno-associated virus (AAV), or herpes simplex virus (HSV), then give two reasons why this specific vector is the most appropriate for your gene therapy. Please explain why you were able to rule out the other potential…In a particular organism, there are two similar genes called YFG1 and YFG2. YFG1 is expressed in the liver and not in the pancreas, and YFG2 is expressed in the pancreas but not the liver. Neither YFG1 nor YFG2 is expressed in the heart. If you extract DNA from heart cells, do you expect to see the YFG2 gene? Explain why. Do you expect to see the YFG1 protein when you analyze protein extract from liver cells? And from pancreas cells? And from heart cells? Explain why. Is it possible to produce YFG1 and YFG2 proteins via alternative splicing? Explain one possible way (mechanism) to regulate the expression of YFG1 gene.Many aspects of gene function can be nicely explained with the one-gene-one-enzyme hypothesis, which states that a gene controls the production of an enzyme. Which of the following findings about gene expression, though, requires an expansion of this simple concept? Choose an answer below: Non-enzyme proteins are made from genes too. Some genes code for RNA molecules only. Enzymes composed of different polypeptides are coded for by more than one gene. a and c, but not b a, b, and c
- Our understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?Like Hurler syndrome, Fabry disease involves an abnormal accumulationof substances within lysosomes. However, the lysosomesof individuals with Fabry disease show an abnormal accumulationof lipids. The defective enzyme is α-galactosidase A, which is alysosomal enzyme that functions in lipid metabolism. The enzymaticdefect causes cell damage, especially to the kidneys, heart,and eyes. The gene that encodes α-galactosidase A is found on theX chromosome. Let’s suppose a phenotypically unaffected coupleproduces two sons with Fabry disease and one phenotypicallyunaffected daughter. What is the probability that the daughter willhave an affected son?All the cells of one organism share the same genome. However, during development, some cells develop into skin cells while others develop into muscle cells. Briefly explain how the same genetic instructions can result in two different cell types in the same organism.
- A gene, which we will call gene C, can be epigenetically modified in such a way that its expression in some cells is permanently silenced. Describe how you could conduct cell-fusion experiments to determine if a cis- or a trans-epigenetic mechanism is responsible for maintaining the silencing of gene C.Due to a nucleotide substitution, the fourth residue of H3 in a specific tissue cell of an organism is no longer lysine. 1. Would this have an impact on Bromodomains or Chromodomains? 2. How would this affect gene expression of that region of the gene in the cell?What is dominant control mechanism of gene expression? explain the following image.