GEF (guanine nucleotide-exchange factor) and GAP (GTPase activating protein) are two regulating proteins of RAS. However, these proteins are in turn regulated by other regulatory proteins. Which change in GAP and GEF can result in excessive proliferation of cells? P. A permanently active GAP Q. A nonfunctional GAP R. Anonfunctional GEF S. A permanently active GEF a. Only P b. P and Q c. Q and S d. Only S

In the RAD signaling pathway the EGF ligand binds the EGF receptor, this initiated a phosphorylation cascade that results in cell proliferation. Which of the following statements is correct: a. RAS protein is the sognal b. EGF ligand is the signal c. cell proliferation is the signal d. EGF receptor is the signal e. none of the above

:= How could changes in signaling molecules affect the toolkit and therefore development? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b Q 13 -6 Toolkit regulation Homework Answered Due May 4th, 9:30 AM с A small modification to a signaling molecule could prevent it from binding to a receptor. All of these are possible outcomes. The signals could bind different promoters. d If the signal recognizes a different enhancer, more or less of some genes will be expressed.

Which of the following statements are correct about the drug Gleevec (select all that apply)?   A. Only inhibits activity of transit amplifying cells   B. Gleevec is a natural product that was identified in a rare plant   C. Negative side effects of drug are inhibition of PDGF and KIT   D. Mutations in ABL gene cause resistance to Gleevec     E. Inhibits the phosphorylation activity of tyrosine kinase