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Explain briefly what does excess amount of creatinine in urine indicate?
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- Answer the following questions: a. Is glucose normally present in urine? In what condition can it be detected in urine? b. In the presence of positive result in Fehling's and Benedict's tests, how would you eliminate the reducing effect of uric acid and creatinine?What is the clinical significance of the presence of glucose in the urine?The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached) a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous? b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter? d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?
- If a patient collects a 24 hour urine specimen with a volume of 1500 mL, and the patient's serum Creatinine is 5 mg/dl, and the urine creatinine is 100 mg/dl, then what is the creatinine clearance in ml/min?Given: A patient’s GFR (glomerular filtration rate) is 125 ml/min, and his urine is produced at a rate of 1.25 ml/min. (A) By what factor is the inulin concentrate in his urine. (B) The concentration of glucose in his plasma is 5 mmol/l. His renal reabsorption of glucose is completely inhibited. What would be the concentration of glucose in his urine? (answer parts a and b)6) Patrick's urine sample reveals a high concentration of glucose. Is glucose normally present in urine? Suggest two possible mechanisms to explain why the kidney would excrete excess glucose, and what abnormality may underlie those conditions.
- The concentration of urea in urine is always much higher than the concentration in plasma. Does this mean that urea is secreted? Hint: remember that concentration is a ratio.Given: For urea, the rate of excretion equals to the GFR times the urea concentration in plasma. (A) If the urea concentration in plasma is 4.5 mmol/l, what GFR (in l/day) would correspond to an excretion rate of 450 mmol/day. (B) If the urea clearance is 70 ml/min and the GFR is 125 ml/min, what fraction of urea is being reabsorbed. (answer A and B)One type of diuretic given to people with high blood pressure, renal disease and congestive heart failure are thiazide-type diuretics. These drugs inhibit sodium ion reabsorption by inhibiting the transport in the ascending limb of the loop of Henle. A) What does it mean to inhibit the transport of sodium ions in the loop of Henle? B) Explain how this inhibition of sodium ions in the loop of Henle could help increase urine production.
- Proteinuria (protein in the urine) after intense exercise may be physiological (normal). However, protein is typically not present in urine. Why is that?A. Maintenance of fluid balance is important for the survival of humans. How does antidiuretic hormone and aldosterone contributes to the maintenance of fluid balance?(ii) High blood pressure can result from increased sodium concentration of plasma. What is the main hormone involved in regulation of sodium and how does it affect the sodium content of blood?(iii) Compare intracellular fluid to extracellular fluid in terms of their chemical composition of proteins, sodium and potassium.(b) Explain the morphological changes that will occur and the driving force when red blood cells are place in (i) 2.0 % sodium chloride solution (ii) 0.9 % sodium chloride solution (iii) 0.01 % sodium chloride solution 1. What are the 4 causes of subarachnoid hemorrhage? 2. State the factors involved in congenital berry or saccular aneurysm 3. Mention 5 specific brain tumors that you know. 4. What is dura mater, arachnoid matter and pia matter? 5. What is meningioma 6. What is acute subdural hematoma 7.…The presence of compounds in urine, depending on the level or range, are indications of underlying disorders. Using glucose as an example, what does the presence of this compound in the urine indicate? And after seeing this compound consecutively in the result, what would be the best course of action to take?
