During the inhibition of glycopeptide transpeptidase, a serine from the enzyme reacts with the amide carbonyl of the lactam ring in penicillin antibiotic to form an enzyme - penicillin complex which inactivates the enzyme. The conversion of an amide to an an ester is not normally observed in reactions of carboxylic acid derivatives. Provide an explanation as to why the amide of a penicillin antibiotic can react with the serine of glyopeptide transpeptidase in this unexpected way.
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
During the inhibition of glycopeptide transpeptidase, a serine from the enzyme reacts with the amide carbonyl of the lactam ring in penicillin antibiotic to form an enzyme - penicillin complex which inactivates the enzyme. The conversion of an amide to an an ester is not normally observed in reactions of carboxylic acid derivatives. Provide an explanation as to why the amide of a penicillin antibiotic can react with the serine of glyopeptide transpeptidase in this unexpected way.
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