Determine whether each of these events of eukaryotic DNA replication is associated with leading strand synthesis or lagging strand synthesis or both. Primase begins RNA polymerization de [ Choose ] novo. DNA polymerase synthesizes DNA 5' to 3' [ Choose ] Ligase joins Okazaki fragments together. [ Choose ] DNA polymerase replaces RNA primers [ Choose ] with DNA. > > > >

DNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional  mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options:   More point mutations will arise in MER-minus yeast.   Fewer point mutations will arise in MER-minus yeast as compared with wildtype.   Of the total point mutations that…

For initiation of replication to occur, DNA topoisomerase and DNA helicase is needed to unwind DNA and break open the DNA double helix respectively. What other enzyme is needed for DNA initiation by DNA polymerase to occur (the answer is not DNA polymerase!)?

The function of the 3'-> 5' exonuclease activity is found in which of the following: DNA Polymerase III DNA Polymerase I DNA Polymerase II All of the above