DNA polymerase 1 has 5' - 3' polymerase activity. 5'-3' exonuclease activity and 3'-5' exonuclease activity necessary for DNA replication. Mutations in the gene that encodes DNA polymerase 1 may cause the enzyme to lose its function.  Match the consequence of the lost function mutation to the corresponding lost activity.

A person with deficient or abnormal ligase may have an increased cancer risk and chromosome breaks that cannot heal. The person is, nevertheless, alive. Why are there no people who lack DNA polymerase?

An Investigator obtains a bacterial temperature-sensitive mutation that affects a step in the process of DNA replication at 42°C but not at 30°C. She grows the cells at 30°C and, upon shifting the temperature to 42°C, she discovers that the DNA remains double- stranded at the replication forks. What is the likely target affected by the temperature-sensitive mutation? DNA Ligase DNA polymerase lII primase DNA gyrase Single-stranded DNA-binding protein (SSB)

Which of the following plays a role in repairing thymine dimers by reversing the damage caused by UV light exposure in bacteria? base excision repair photoreactivation enzyme postreplication repair non-homologous end-joining repair DNA polymerase proofreading

besides DNA pol I and DNA pol III What are the roles of the other enzymes involved in replication and why they're necessary ?

Which of the following enzymes has a major role in joining of DNA fragments (Okasaki fragments) during DNA replication? Group of answer choices DNA gyrase Helicase Primase DNA polymerase DNA ligase

Hereditary nonpolyposis colon cancer (HNPCC) is caused by mutations in proteins from one of the DNA repair pathways. Which pathway is it and what are the protein activities occuring in the pathway?

What is an example of a disease or a disorder that results from an error in DNA replication? What kind of DNA replication error is involved?

Which of the following DNA repair processes is known to be "error-prone" (i.e. resulting in incorporation of incorrect nucleotides as part of the repair process)? Mark all the answers that are correct. Base Excision Repair (BER) non-homologous end-joining of double-stranded DNA breaks. O Nucleotide Excision Repair (NER) post-replication repair SO-response

Using the numbered sites on the DNA double helix strands below, where would the DNA Primer ACTTGCGA bind to for DNA Amplification?