Describe the role of the proteostasis network.

21.  Pancreatic beta cells secrete the protein hormone insulin in response to various signals. Which of the following is/are true of these cells?     a)  They would have high concentration of insulin stored in membrane-bound vesicles adjacent to the plasma membrane.   b)  They would contain more mitochondria than an average cell.   c)  They participate in regulated secretion.   d)  a and c   e)  a, b and c

What is a genetic mutation? How do they influence the synthesis of proteins and/or the onset of disorders?

what organelle is responsible for the malfunction of the production of abnormmally low levels of the protein insulin?

Define and explain with appropriate examples: Lactonization and Lactamization ?

Which protein in G-protein cascades plays a role similar to that of elongation factor Ts?

Explain the genetic alterations resulting in protein synthesis defects and their relationship to disease processes such as sickle cell anemia and polycystic kidney disease.

Activation of which of the following enzymes stimulates glycogen synthesis? a) Protein kinase B b) Glycogen synthase kinase 3 c) Both a and b d) Neither a nor b

Explain the role of the mitochondria in apoptosis.

I am creating a medical scaffold made out of TPU to surgically implant around the pancreas for diabetic patients. The scaffold will have have capsules of islet beta cells which will diffuse into the pancreas to create a functional pancreas. I will use the Brunauer–Emmett–Teller (BET) technique to determine the specific surface area and porosity of the scaffold material. In the context of the TPU scaffold, the BET technique will provide crucial insights into its porosity and its potential to facilitate the infusion of beta cells into the pancreas.  Can you explain the expected/ideal results from the BET test and how the test will help the design process of this medical scaffold.