Consider the two very limited unrelated pedigrees shown here. Of the four combinations of X-linked recessive, Xlinked dominant, autosomal recessive, and autosomal dominant, which modes of inheritance can be ruled out in each case? (a) (b) 2 2
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- a) Identify and describe 5 different types of genetic inheritance.(b) In humans, glucose-6-phosphate dehydrogenase deficiency is a recessive X-linkedtrait. Describe the inheritance of this disease, including an example of the possibleoutcomes of:(i) An affected mother and an unaffected father having children. (ii) An affected father and a homozygous unaffected mother having childrenHypophoshatemia is a dominant genetic disorder caused by deficiency of pho[hates in the blood. Assuming the other parent is free of the disorder, males with the disorder will pass it on to all their daughters but not their sons. Females with the disorder will pass it on to approximately half of their children. a.) Is this pattern of inheritance autosomal or sex-linked? Explain b.) Draw a Punnett square to show the inheritance pattern of the disorder in each of the two scenariosWhat is the most likely pattern of inheritance for this disorder? (Is it autosomal dominant? Autosomal recessive? X-linked dominant? X-linked recessive? Y-linked? Mitochondrial?) Please include two specific pieces of evidence, present within the pedigree, that indicate that this pattern is most likely, as opposed to any other potential pattern. You may assume that the gene responsible for the trait is fully penetrant.
- Albinism in humans is inherited as a simple recessive trait.Determine the genotypes of the parents and offspring for the following families. When two alternative genotypes are possible,list both.(a) Two parents without albinism have five children, four withoutalbinism and one with albinism.(b) A male without albinism and a female with albinism havesix children, all without albinism.Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.) (a) Two normal parents have five children, four normal and one albino. (b) A normal male and an albino female have six children, all normal. (c) A normal male and an albino female have six children, three normal and three albino. (d) Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).6) For the pedigree shown below, answer the following questions. I II III a) What type of inheritance is shown? Explain how you know. b) The genotype of individual I -2 is The genotype of individual II -1 is
- In 1995, doctors reported a Chinese family in whichretinitis pigmentosa (progressive degeneration of theretina leading to blindness) affected only males. Allsix sons of affected males were affected, but all of thefive daughters of affected males (and all of thechildren of these daughters) were unaffected.a. What is the likelihood that this form of retinitispigmentosa is due to an autosomal mutationshowing complete dominance?b. What other possibilities could explain the inheritance of retinitis pigmentosa in this family? Whichof these possibilities do you think is most likely?What genetic criteria distinguish a case of extranuclear inheritance from (a) a case of Mendelian autosomal inheritance; (b) a case of X-linked inheritance?Albinism, lack of pigmentation in humans, results from an autosomal recessive gene (a). Two parents with normal pigmentation have an albino child. (a) What is the probability that their next child will be albino? (b) What is the probability that their next child will be an albino girl? (c) What is the probability that their next three children will be albino?
- TO င် ၅ဝပ် တွင် တွင် ၏ ဝ DO (A) The blue trait is inherited as an autosomal recessive trait which means that affected individuals have copies of a mutant gene. (B) Indicate which individuals are carriers of the "blue" gene by placing the letters Bb next to their symbol. (C) What is the relationship of the parents of the "blue" children? (D) What is the probability that the unaffected siblings of the "blue" children are carriers for the "blue" trait? (E) What warning does marrying close relatives does this illustrate?2(a) Red-green color blindness is inherited as a recessive X-linked trait. What is the probability that a woman with phenotypically normal parents and a color-blind brother will have a color- blind son? Assume that she has no previous children. 2(b)If the woman (phenotypically normal) in question 2(a) already had a color-blind son, what is the probability that the next child of the phenotypically normal woman will have a color- blind son? Short Answer. Please provide your final answer as a fraction Answer 2b only2(a) Red-green color blindness is inherited as a recessive X-linked trait. What is the probability that a woman with phenotypically normal parents and a color-blind brother will have a color- blind son? Assume that she has no previous children. 2(b)If the woman (phenotypically normal) in question 2(a) already had a color-blind son, what is the probability that the next child of the phenotypically normal woman will have a color- blind son? 2Lc) If the woman (phenotypically normal) in question 2(a) married to a color-blind man and already had a color-blind son, what is the probability that they will have a color-blind daughter? Short Answer. Please provide your final answer as a fraction Answer 2C only