Consider the two very limited unrelated pedigrees shown here. Of the four combinations of X-linked recessive, Xlinked dominant, autosomal recessive, and autosomal dominant, which modes of inheritance can be ruled out in each case? (a) (b) 2 2

In human beings, the gene for red‑green colorblindness (r) is sex‑linked and recessive to its allele for normal vision (R), while the gene for freckles (F) is autosomal and dominant over its allele for nonfreckled (f).  A nonfreckled, normal‑visioned woman whose father was freckled and colorblind, marries a freckled, colorblind man whose mother was nonfreckled. What is the probability that the first child born to the couple will either be a freckled, colorblind boy or a non‑freckled, normal visioned girl or a non-freckled, normal visioned boy?   What is the probability that the first four children born to the couple will be freckled and normal visioned girls?

Which of the 6 modes is this pedigree and why? 1) Autosomal Dominant 2) Autosomal Recessive 3) X-linked Recessive 4) X - linked Dominant 5) Y-Linked 6) mt-Linked

An unaffected woman for a human disorder marries and unaffected man and they have children. This results in 3 affected sons, and one unaffected daughter, which ends up having children later on with an unaffected man and has 2 affected sons. A) Draw a simple pedigree diagram for this family, including a legend. B) What is the likely mode of inheritance of this trait: Please explain C) Provide the genotypes of the original mother and the daughter. Use a capital letter for the dominant allele and lowercase letter for the recessive allele. D) If one of the affected sons from the original marriage marries a 2nd cousin that is a carrier of this trait and has children, what is the probability that they will have 3 affected sons?

The Pedigree shown is O O 마ㅇ ㅇㅇㅇ 이탕 - ㅁㅁㅇㅁ 5 A) Autosomal Dominant B) Sex linked recessive C) Autosomal Recessive D) Sex linked dominant

The following pedigree illustrates the inheritance of ringed hair, a condition in which each hair is differentiated into light and dark zones. What mode or modes of inheritance are possible for the ringed-hair trait in this family? 2 II 2 3 4 5 6 II 2 3 4 5 IV

The pedigree shows a family in which several members have suffered from one and the same disease (look at the picture to be able to answer) a) Is it a dominant or recessive allele that causes the disease? Motivate your answer. b) Is allele autosomal or sex-linked? Motivate your answer. c) What is the probability that III-3 and III-4 will have a healthy child? Motivate your answer.