Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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### Glucose Metabolism: Reaction Sequence

Consider the following reaction sequence:

\[ \text{glucose 1-phosphate} + \text{UTP} \rightarrow \text{UDP-glucose} + \text{pyrophosphate} \]

\[ \text{UDP-glucose} + (\text{glucose})_n \rightarrow \text{UDP} + (\text{glucose})_{n+1} \]

### Question: 
Which of the following characterizes this process?

- \(\bigcirc\) consumes energy
- \(\bigcirc\) all of these
- \(\bigcirc\) anabolic
- \(\bigcirc\) a step in gluconeogenesis

### Explanation:
In this reaction sequence, glucose 1-phosphate interacts with UTP (Uridine Triphosphate) to form UDP-glucose (Uridine Diphosphate glucose) and pyrophosphate (inorganic phosphate group). UDP-glucose then adds to an existing glucose chain (\( (\text{glucose})_n \)), elongating it by one glucose unit (\((\text{glucose})_{n+1}\)) and releasing UDP.

**Terms Explained:**

- **Consumes energy:** This process requires energy input, primarily from UTP, to form the UDP-glucose.
  
- **All of these:** This option suggests that the process is energy-consuming, anabolic, and a step in gluconeogenesis.
  
- **Anabolic:** This implies that the process involves building larger molecules (in this case, glycogen or glucose chains) from smaller units (UDP-glucose).

- **A step in gluconeogenesis:** Gluconeogenesis is the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. The process described is more closely associated with glycogenesis (formation of glycogen) rather than gluconeogenesis.

This sequence is an essential part of the metabolism of glucose, primarily associated with the biosynthesis of glycogen. This is an anabolic process that consumes energy in the form of UTP and is involved in the storage of glucose in the form of glycogen.
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Transcribed Image Text:### Glucose Metabolism: Reaction Sequence Consider the following reaction sequence: \[ \text{glucose 1-phosphate} + \text{UTP} \rightarrow \text{UDP-glucose} + \text{pyrophosphate} \] \[ \text{UDP-glucose} + (\text{glucose})_n \rightarrow \text{UDP} + (\text{glucose})_{n+1} \] ### Question: Which of the following characterizes this process? - \(\bigcirc\) consumes energy - \(\bigcirc\) all of these - \(\bigcirc\) anabolic - \(\bigcirc\) a step in gluconeogenesis ### Explanation: In this reaction sequence, glucose 1-phosphate interacts with UTP (Uridine Triphosphate) to form UDP-glucose (Uridine Diphosphate glucose) and pyrophosphate (inorganic phosphate group). UDP-glucose then adds to an existing glucose chain (\( (\text{glucose})_n \)), elongating it by one glucose unit (\((\text{glucose})_{n+1}\)) and releasing UDP. **Terms Explained:** - **Consumes energy:** This process requires energy input, primarily from UTP, to form the UDP-glucose. - **All of these:** This option suggests that the process is energy-consuming, anabolic, and a step in gluconeogenesis. - **Anabolic:** This implies that the process involves building larger molecules (in this case, glycogen or glucose chains) from smaller units (UDP-glucose). - **A step in gluconeogenesis:** Gluconeogenesis is the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. The process described is more closely associated with glycogenesis (formation of glycogen) rather than gluconeogenesis. This sequence is an essential part of the metabolism of glucose, primarily associated with the biosynthesis of glycogen. This is an anabolic process that consumes energy in the form of UTP and is involved in the storage of glucose in the form of glycogen.
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