Below is a pedigree of a human blinding disease. Use this pedigree to answer the following questions. d 18 14) If this is disease has an autosomial recessive inheritance pattern, what is the probability that individuals II-3 and II-4 have four more children and three of them are affected by the disease? a) 4.68% b) 1.17% c) 7.03% d) 42.18% e) 1.56%

PKU is a recessive disorder based on a single mutant gene. Consider that Noor is a carrier, but her partner Hamza has never had an incidence of PKU show up in his family history, which dates back to four generations. What is the likelihood their first child might develop PKU according to their genetics counselor?   a)    100%!   b)    50%   c)   25%   d)   0%

23. What is the probability that the progeny of a cross between two individuals that are AABBCCDD will have the same genotype as the parents? A) 1/256 B) 1/16 C) 1/4 D) 1 24. Which of the following inheritance patterns describes the ability of a single allele to have multiple phenotypic effects? A) incomplete dominance B) multiple alleles C) pleiotropy D) epistasis 25. Phenylketonuria (PKU) is an inherited disease caused by a recessive autosomal allele. If two individuals are both carriers, what is the probability that their first child will be a carrier for PKU? A) 1/4 В) 1/2 С) 3/16 D) 3/8

Sickle-cell disease is a recessive trait in humans. In a cross between a father who has sickle-cell disease and a mother who is heterozygous for the sickle-cell allele, what is the probability that all of their first three children will be unaffected? A) 1/4B) 1/2C) noneD) 1/8E) 1/16

1. The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: || IV 3 9 10 5 2 C 6 11 T 7 12 8 15 13 16 14 17 d) What is the genotype for individual #4 in this family pedigree? ||| c) Why are no family members identified as a carrier of this genetic disorder? Figure Key a) Using the figure key provided, identify which members of this family are affected by this genetic disorder in each generation. (Be sure to include sex and generation number for each individual identified). b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain. Unaffected Female Unaffected Male Affected Female ||| Affected Male Female Carrier Male Carrier

There are 3 possible diploid genotypes at a locus with 2 alleles. a) True b) False

Sickle cell anemia is a recessive trait in humans. In a cross between a father who has sickle cell anemia and a mother who is heterozygous for the sickle cell allele, what is the probability that both of their first two children will be affected? A) none B) 1/16 C) 1/8 D) ¼ E) ½

Cystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. a) What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places.  b) What percentage of the Caucasian population would be carriers for cystic fibrosis? Show all your work and express your answer rounded to two decimal places.  c)If two individuals are carriers of the cystic fibrosis allele, what is the probability that they would have a girl without cystic fibrosis? Show all your work (including the Punnett square) and express your answer as a value between 0 and 1 rounded to two decimal places.

An unaffected woman for a human disorder marries and unaffected man and they have children. This results in 3 affected sons, and one unaffected daughter, which ends up having children later on with an unaffected man and has 2 affected sons. A) Draw a simple pedigree diagram for this family, including a legend. B) What is the likely mode of inheritance of this trait: Please explain C) Provide the genotypes of the original mother and the daughter. Use a capital letter for the dominant allele and lowercase letter for the recessive allele. D) If one of the affected sons from the original marriage marries a 2nd cousin that is a carrier of this trait and has children, what is the probability that they will have 3 affected sons?

The Pedigree shown is O O 마ㅇ ㅇㅇㅇ 이탕 - ㅁㅁㅇㅁ 5 A) Autosomal Dominant B) Sex linked recessive C) Autosomal Recessive D) Sex linked dominant