The pedigree pictured is of an extended family where a large percentage of family members develop colon cancer at an early age. In this family, individuals either get colon cancer before the age of 16, or they don’t get it at all. a) Based on the information you have been given, what evidence, if any, suggests an inherited contribution to the development of this disease? b) You take a medical history of all 33 people in the pedigree and discover that a large percentage drink a special coffee on a daily basis, while others do not. The individuals who do not drink coffee are I-1, II-2, II-4, II-9, III-7, III-13, IV-1, and IV-3.  Could drinking this special coffee play a role in colon cancer? Explain.

In fruit flies, yellow body is a sex linked recessive allele. The dominant allele is dark bodied. If a female with a yellow body mates with a male with a dark body, then what percent of the male offspring will be yellow? O O O O a) 0 b) 25 c) 50 d) 75 e) 100

Divya is 32 years old. She has found a small lump in her left breast and decided to go to her GP for a check-up. Her GP examined her and asked whether terse was any family history of cancer. She said her sister had breast cancer and he mother had died of ovarian cancer. Divya said there were also cases of cancer within her extended family. The pedigree below shows 3 generations of Divya’s family. The GP analysed the pedigree and concluded there was likely to be an inherited mutation running through Divya’s family and immediately referred her for a mammogram and a biopsy of the lump. Tissue from the biopsy was set for gene testing. Part 1 What type of inherited cancer syndrome appears to be present in Divya’s family? Part 2 What is the name of the gene being tested for matrons and what gene class does it belong to? Part 3 Are inherited mutations in this gene loss of function, gain of function or silent? Would you expect an individual to inherit a mutation in both parental copies of this…

what is the probability that a couple (both heterozygous for the same recessive mutation) will have two children with the disease if the couple plans to have four children in total?

What causes most of the phenotypic abnormalities in someone with Down's Syndrome? A) They have many gene mutations that produce nonfunctional proteins. B) They express too much of some proteins during development. C) Their cells cannot go through mitosis properly during development because they have an odd number of chromosomes. D) Their chromosomes cannot pair during meiosis.

9 a,b,c

Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. For unknown reasons, the allele is more common in populations of Ashkenazi Jews of eastern Europe. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease.a. Draw the relevant parts of the pedigree, and show all the genotypes as completely as possible. b. What is the probability that the cousins’ first child will have Tay-Sachs disease, assuming that all people who marry into the family are homozygous normal?

PKU is a recessive disorder based on a single mutant gene. Consider that Noor is a carrier, but her partner Hamza has never had an incidence of PKU show up in his family history, which dates back to four generations. What is the likelihood their first child might develop PKU according to their genetics counselor?   a)    100%!   b)    50%   c)   25%   d)   0%

Sickle-cell disease is a recessive trait in humans. In a cross between a father who has sickle-cell disease and a mother who is heterozygous for the sickle-cell allele, what is the probability that all of their first three children will be unaffected? A) 1/4B) 1/2C) noneD) 1/8E) 1/16

Produce a pedigree diagram to convey the information shown. Gill, has come along to the Genetic Clinic with her younger sister, Charlotte. They have been invited because Charlotte’s youngest child, Jamie, who is 10 months old, is experiencing multiple, recurring parallel infections. Jamie has two very healthy older siblings, the eldest is his sister, Penny, and the middle child is his brother, Charlie. Gill’s youngest child, her son, Tom, is only 18 months old but has been in constant contact with the hospital since he was born. He has had recurrent bouts of pneumonia, bronchitis, otitis, conjunctivitis, and sinusitis. He often has diarrhoea and, due to the incredible strain on his small body, he is failing to thrive. Thankfully his medical team were thorough in their investigations, and he has just been diagnosed with X-linked agammaglobulinemia. Tom has two older siblings, the youngest of whom, Ella, was conceived as a twin, though IVF, but her twin died in utero at about 9 weeks…