Base in second position A UUU UCU UAU UGU Phe Tyr UGC Stop UGA Stop A Stop UGG Trp G Cys UUC UCC UAC Ser UUA UCA UAA >Leu UUG UCG UAG CGU His CGC CUU CCU CAU CUC CC CÁC >Leu Pro Arg CỦA CCA САА CGA Gin CUG CCG CAG CGG G AUU ACU AAU AGU Asn Ser AUC >lle A AUA ACC AAC AGC Thr ACA AAA AGA Lys AAG Arg AUG Met/ ACG AGG start GAU Asp GAC GUU GCU GGU GGC Gly GUC GCC Val Ala GUA GCA GAA GGA A Glu GUG GCG GAG GGG A FIGURE 5.17 The genetic code. The table is arranged so that users can quickly find any amino acid from the three bases of the MRNA codon (written in the 5' -→3' direction). For example, to find the amino acid corre- sponding to the codon 5' AUC 3', look first in the A row, then in the U col umn, and finally in the C space, which indicates that the amino acid is lle. Base in third position (3' end) Base in first position (5' end)
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Sickle-cell disease is caused by a so-called point mutation in the human
β - globin gene. A point mutation is the result of a single base substitution in
the DNA encoding a gene. The sickle-cell mutation results in the substitution
of Val for Glu at position 6 in the β - globin protein.
(a) Using the information in as shown, explain how a point mutation
could change a codon for Glu to a codon for Val.
(b) Do you expect the pI for the sickle-cell β - globin to be higher or lower
than the pI for wild-type β-globin ? Explain.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
