Mutations to SRP72 (the RNA component of the signal recognition particle) are known to cause some forms of familial bone marrow failure. Which of the following protein(s) is/are potentially affected by such deleterious mutations? Choose all that apply Epidermal growth factor receptor (EGFR) Cytochrome c Insulin (a secreted protein) uS7 (a small ribosamal subunit protein from all domains of life) 0000

AAA is a protein found in both the cytosol as well as the nucleus. In its active state, it helps to facilitate the movement of proteins into and out of the nucleus. Specifically, AAA-alpha and AAA-beta binds to receptors on the nucleus and allows for materials to enter or exit through the channels associated with the receptors. They also play a role in dropping off cargo that import and export receptors hold onto. AAA functions are controlled by two other proteins: BBB and CCC. BBB binds onto AAA, while CCC removes BBB from AAA when they are bound. As a result, there is a BBB and CCC concentration gradient that forms between the cytosol and nucleus. During prophase I, is there a concentration gradient for BBB and CCC between the cytosol and the nucleus? Why? Is this also the case during the other phases of meiosis or the cell cycle?

Long non-coding RNAs (lncRNA) can act as a scaffold to form protein/RNA complexes that regulate gene expression?     True     False   Wnt is a regulatory factor that regulate myogenic stem cell proliferation?     True     False

Choose the statement that correctly characterizes regulated and/or constitutive gene expression. Regulated expression refers to gene expression that is either on or off, depending on the physiological or metabolic status of the cell. Constitutive expression refers to gene expression that is either on or off, depending on the physiological or metabolic status of the cell. Constitutive expression refers to gene expression that is always repressed in response to the absence of required nutrients or other metabolic molecules. Regulated expression refers to gene expression that is always on, regardless of the metabolic or physiological conditions in the cell. Regulated and constitutive expression are terms used to describe gene expression in prokaryotes only.

How would a human cell normally change its expression of the gene for tyrosine aminotransferase? adipose cells will turn on this gene in the presence of glucocorticoids liver cells will turn on this gene in the presence of glucocorticoids liver cells will turn on this gene in the absence of glucocorticoids liver cells will turn off this gene in the presence of glucocorticoids  adipose cells will turn off this gene in the absence of glucocorticoids

A human gene called theCFTR gene (for cystic fibrosis transmembrane regulator) encodes aprotein that functions in the transport of chloride ions across the cellmembrane. Most people have two copies of a functional CFTR geneand do not have cystic fibrosis. However, a mutant version of the CFTRgene is found in some people. If a person has two mutant copies ofthe gene, he or she develops the disease known as cystic fibrosis. Arethe following descriptions of this disease related to genetics at themolecular, cellular, organism, or population level?A. People with cystic fibrosis have lung problems due to a buildupof thick mucus in their lungs.B. The mutant CFTR gene encodes a defective chloride transporter.C. A defect in the chloride transporter causes a salt imbalance inlung cells.D. Scientists have wondered why the mutant CFTR gene is relativelycommon. In fact, it is the most common mutant gene that causesa severe disease in persons of Northern European descent. Onepossible explanation why…

ERAD, or ER associated degradation, is a quality control measure with the following function: A. misfolded proteins activate the expression of genes such as chaperones that will help to refold and stabilize misfolded proteins until the fold correctly B. proteins that cannot fold correctly are ejected from the ER through the translocon and degraded by the ubiquitin-proteasome system in the cytosol C. misfolded proteins are ubiquitinated and degraded by proteasomes inside the ER D. Unfolded proteins in the ER activate a transmembrane kinase in the ER that phosphorylates misfolded proteins that are sent to the lysosome in vesicles for degradation

Most diseases are caused by disruptions in cellular function. You are to research a disease that is a disturbance at the cellular level. Usually, there are problems with the organelles within the cells. So essentially, you can look up things like....mitochondrial diseaselysosomal disorderscellular receptor disorders Once you have found a disease you should include the following in your 2 paragraph summary.1-Description and how is occurs2-Is it genetic?3-Are there cures?4-What does research show as far as cures or treatments?5-How does it affect one's life?

Ras is a proto-oncogene that is within the EGF pathway. The EGF receptor can activate the cell division pathway only when the EGF ligand binds to the receptor. A gain of function mutation occurs in only one copy of the Ras gene. What are all the possible consequences of this? Select all that apply. Group of answer choices The cell will undergo constant cell division The cell will still be normal as only one copy of Ras is mutated. Both copies must be mutated for the cell to undergo constant cell division There will be an increase of EGF ligands present in the cell The EGF receptor will always be active even with no EGF ligands bound and activate the pathway Ras will always be active and activate the proteins downstream that will turn on cell division Ras will be under the influence of the EGF receptor and will only activate if the EGF ligand is bound to the receptor

ErbB receptors (Epidermal growth factor receptors) bind selectively to different growth factors. Determine what are the ErbB growth factors and which ErbB receptor(s) they bind to?